2022
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis
Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.Peer-Reviewed Original ResearchConceptsChest tube outputQuality of evidenceCardiopulmonary bypassTranexamic acidCardiac surgeryMean decreaseTube outputPlatelet requirementsPlatelet transfusionsML/P-valueMeta-analysisSystematic reviewStandardized data extraction toolBlood product requirementsPediatric cardiac surgeryPlasma requirementsPreferred Reporting ItemsData extraction toolWeb of SciencePostoperative bleedingCyanotic patientsPlasma transfusionBlood lossRBC transfusion
2020
Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation.
Karam O, Goel R, Dalton H, Nellis ME. Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. Critical Care Medicine 2020, 48: e698-e705. PMID: 32697511, DOI: 10.1097/ccm.0000000000004417.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkChest tube outputMembrane oxygenationHemostatic transfusionsRBC transfusionTransfusion doseExtracorporeal membrane oxygenation daysLarge observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkTube outputPlatelet transfusion doseObservational cohort studyHuman Development Collaborative Pediatric Critical Care Research NetworkInternational normalized ratioTotal platelet countPartial thromboplastin timeAntithrombin levelsCohort studyConsecutive childrenTransfusion strategyChest tubePlatelet countHemostatic testingThe Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period
Stawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Bellumkonda L, Lee F, Chen M, Jacoby D, Chou J, Ahmad T, Testani J, McCloskey G, Bonde P. The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period. The Journal Of Heart And Lung Transplantation 2020, 39: s151-s152. DOI: 10.1016/j.healun.2020.01.1087.Peer-Reviewed Original ResearchRight ventricular failureVentricular failureMedian sternotomyLeft ventricular assist deviceBlood product useChest tube outputGiant cell myocarditisPoor surgical candidatesPulmonary vascular resistanceSingle-center experienceEarly postoperative periodStandard median sternotomyVentricular assist deviceMann-Whitney testIABP useINTERMACS profileMS implantationRVAD placementRVAD useLess transfusionRV dilationSurgical candidatesVascular resistanceAdverse eventsLVAD patients
2018
Fish Oil and Perioperative Bleeding
Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, Tavazzi L, Latini R, Pretorius M, Brown NJ, Libby P, Mozaffarian D. Fish Oil and Perioperative Bleeding. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004584. PMID: 30571332, PMCID: PMC6376981, DOI: 10.1161/circoutcomes.118.004584.Peer-Reviewed Original ResearchConceptsBleeding Academic Research Consortium bleedingPerioperative bleedingFish oil supplementationFish oil groupLower riskPrimary outcomeFish oilMean ageOil supplementationOil groupBleeding Academic Research ConsortiumPlasma phospholipid omega-3Coronary artery bypass graftMajor perioperative bleedingChest tube outputPlacebo-controlled trialAcademic Research ConsortiumArtery bypass graftTreatment of hypertriglyceridemiaAbsolute risk differenceParticipants' mean ageHealth care professionalsFatty acid levelsBleeding definitionsHemostasis definition
2011
Clinical Significance of Coagulation Studies in Predicting Response to Recombinant Factor VIIa in Cardiac Surgery Patients
Lee A, Campigotto F, Rawn J, Neuberg D, Kaufman R, Berliner N. Clinical Significance of Coagulation Studies in Predicting Response to Recombinant Factor VIIa in Cardiac Surgery Patients. Blood 2011, 118: 4351. DOI: 10.1182/blood.v118.21.4351.4351.Peer-Reviewed Original ResearchChest tube outputCardiac surgery patientsCoagulation studiesCardiac surgeryUncontrolled hemorrhageTube outputRFVIIa administrationRFVIIa efficacyTransfusion requirementsSurgery patientsRetrospective studyMedical recordsSurvival statusMedian cardiopulmonary bypass timeMultivariable logistic regression analysisStepwise multivariable logistic regression analysisCardiopulmonary bypass timeMedian transfusion requirementStepwise multivariable regression modelsBlood product transfusionVentricular ejection fractionIntraaortic balloon pumpRecombinant factor VIIaLogistic regression analysisMultivariable regression modelsProspective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology
Todd Tzanetos DR, Yu C, Hernanz-Schulman M, Barr FE, Brown NJ. Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology. Intensive Care Medicine 2011, 38: 105-112. PMID: 21979273, PMCID: PMC4747610, DOI: 10.1007/s00134-011-2378-y.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCentral Nervous SystemChild, PreschoolFemaleHeart Defects, CongenitalHeart VentriclesHospitals, PediatricHumansInfantInfant, NewbornMaleMedical AuditPalliative CarePerioperative CarePostoperative ComplicationsPredictive Value of TestsProspective StudiesTennesseeThrombosisUltrasonographyConceptsSingle ventricle physiologyTissue plasminogen activator antigenCardiopulmonary bypass timePlasminogen activator antigenPlasma antithrombin IIIVentricle physiologyAntithrombin IIIBypass timePalliative surgeryVentricular functionTissue plasminogen activator antigen concentrationAortic cross-clamp timeCentral venous catheter daysLonger cardiopulmonary bypass timePoor preoperative ventricular functionPredictors of thrombusPreoperative ventricular functionChest tube outputCross-clamp timeBiomarkers of coagulationBlood product administrationLow antithrombin IIICentral venous systemIntensive care unitPlasminogen activator inhibitor-1
2008
Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes
Balsam L, Timek T, Pelletier M. Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes. Journal Of Cardiac Surgery 2008, 23: 614-621. PMID: 18793226, DOI: 10.1111/j.1540-8191.2008.00686.x.Peer-Reviewed Original ResearchConceptsChest tube outputBlood product utilizationPostoperative bleedingTube outputReview of clinical outcomesAdministration of blood productsAdministration of FEIBACardiac surgical proceduresInhibitor bypassing activityMultisystem organ failureCardiac surgery programFEIBA administrationRefractory bleedingCardiac surgerySurgical reexplorationRetrospective reviewRespiratory failureThrombotic eventsClinical outcomesMultiple dosesSingle doseFEIBAOrgan failureOperative reexplorationExtremity ischemia
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