2011
Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice
Charchaflieh JG, Torres H, Cottrell JE, Kass IS. Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice. Journal Of Neurosurgical Anesthesiology 2011, 23: 146-149. PMID: 21270645, DOI: 10.1097/ana.0b013e31820592d1.Peer-Reviewed Original ResearchConceptsMinutes of hypoxiaRat hippocampal slicesPosthypoxic hypothermiaElectrophysiological recoveryModerate hypothermiaHippocampal slicesCA1 pyramidal cell layerMale Sprague-Dawley ratsHypoxic neuronal injuryPyramidal cell layerSprague-Dawley ratsHours of recoveryNeuronal injuryProtective effectStudy groupInstitutional Animal CareAnimal studiesControl groupHypothermiaElectrophysiological recordingsHypoxiaCell functionUse CommitteeCell layerAnimal care
2004
Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity within a Living Synapse*
Jonas EA, Hickman JA, Hardwick JM, Kaczmarek LK. Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity within a Living Synapse*. Journal Of Biological Chemistry 2004, 280: 4491-4497. PMID: 15561723, DOI: 10.1074/jbc.m410661200.Peer-Reviewed Original ResearchConceptsMitochondrial channel activityMitochondrial membraneChannel activityBcl-xLBcl-2 family proteinsPro-apoptotic fragmentsOuter mitochondrial membraneTrigger cell deathZ-VAD-FMKBenzyloxycarbonyl-VADFamily proteinsSynaptic responsesMulticonductance channelLarge conductance channelFluoromethyl ketoneCell deathMinutes of hypoxiaResponses of neuronsNeuronal functionSquid giant synapseSynaptic mitochondriaEarly eventsSynaptic functionHypoxic conditionsNeuronal death
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