2024
N-Methyl-D-aspartic acid (NMDA) mediated vasodilation in aorta
Yilmaz G, Alexander J. N-Methyl-D-aspartic acid (NMDA) mediated vasodilation in aorta. Physiology 2024, 39: 2323. DOI: 10.1152/physiol.2024.39.s1.2323.Peer-Reviewed Original ResearchN-methyl-D-aspartic acidNitric oxide synthaseVascular smooth muscleVascular responsesSmooth muscleN-methyl-D-aspartic acid receptor blockadeResponse to NMDAWild type male miceNMDA-induced vasodilationNon-NMDA receptorsIn vitro myographyThoracic aorta segmentsPeripheral vascular responseMK-801Receptor blockadeNMDA concentrationsNMDA receptorsResistance arteriesEndothelial cell layerL-NAMEOsmolarity solutionVasodilatory effectMethyl ester hydrochlorideAortic segmentsInduce vasodilation
2022
Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier
Tian X, Bunda P, Ishibe S. Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier. Frontiers In Medicine 2022, 9: 801837. PMID: 35223901, PMCID: PMC8866310, DOI: 10.3389/fmed.2022.801837.Peer-Reviewed Original ResearchPlasma membrane componentsHuman genetic mutationsGlomerular filtration barrierEndocytosis genesEndocytic machineryFiltration barrierTransmembrane receptorsBiological functionsVesicle formationSignaling pathwaysEndocytosisMembrane componentsPodocyte functionCellular endocytosisNovel insightsProteinuric glomerular diseasesAdjacent basement membraneGenetic mutationsFunction studiesEpithelial cellsPathwayEndothelial cell layerBasement membraneImportant roleCell layer
1998
The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis.
Graesser D, Mahooti S, Haas T, Davis S, Clark R, Madri J. The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitis. Laboratory Investigation 1998, 78: 1445-58. PMID: 9840619.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell AdhesionCell MembraneCell MovementCells, CulturedClone CellsEncephalomyelitis, Autoimmune, ExperimentalEndothelium, VascularGelatinasesIntegrin alpha4Matrix Metalloproteinase 14Matrix Metalloproteinase 2Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMiceMice, Inbred StrainsProtease InhibitorsTissue Inhibitor of Metalloproteinase-2T-LymphocytesTransfectionConceptsExperimental autoimmune encephalomyelitisT cell clonesRecombinant vascular cell adhesion molecule-1Autoreactive T cell clonesAlpha4 integrinsMMP-2EAE inductionAutoimmune encephalomyelitisMyelin basic protein-reactive T cell clonesDisease processMatrix metalloproteinaseVascular cell adhesion molecule-1Cell adhesion molecule-1Human multiple sclerosisSusceptible mouse strainsAdhesion molecule-1T cell transmigrationMatrix metalloproteinase-2Microvascular endothelial cellsAlpha4 integrin expressionExpression of alpha4Adoptive transferMultiple sclerosisMouse modelEndothelial cell layer
1994
The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.
Romanic A, Madri J. The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. Journal Of Cell Biology 1994, 125: 1165-1178. PMID: 7515069, PMCID: PMC2120055, DOI: 10.1083/jcb.125.5.1165.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1Recombinant VCAM-1T cellsT cell transmigrationEndothelial cellsNegative endothelial cellsCell transmigrationCell adhesion molecule-1Transmigrated T cellsExperimental autoimmune encephalomyelitisT cell extravasationAdhesion molecule-1Late antigen-4VCAM-1 positive cellsMyelin basic proteinAutoimmune encephalomyelitisEndothelial cell monolayersAntigen-4Brain parenchymaNormal miceEndothelial cell layerPositive cellsMolecule-1Perivascular tissueT cell adhesion
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