Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Kim H, Shim Y, Choi S, Kim M, Lee G, You H, Choi W, Yang K, Ryu T, Kim K, Kim M, Woo C, Chung K, Hong S, Eun H, Kim S, Ko G, Park J, Gao B, Kim W, Jeong W. Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. Experimental & Molecular Medicine 2023, 55: 158-170. PMID: 36631664, PMCID: PMC9898237, DOI: 10.1038/s12276-022-00921-x.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseApoptotic Kupffer cellsKupffer cellsSingle-cell RNA sequencingCatecholamine levelsLiver diseaseKupffer cell apoptosisPortal bloodGrowth differentiation factor 15Chronic ethanol intakePathogen challengeChronic alcohol exposureApoptotic genesChronic alcohol consumptionB2 adrenergic receptorDifferentiation factor 15Effects of catecholaminesEthanol-fed miceExpression of ADRB2KC apoptosisChronic ethanol-fed miceGrowth differentiation factorRegulatory roleCell apoptosisGenetic ablation
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