2025
CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting
Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth F. CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting. ELife 2025, 12: rp89459. PMID: 39945513, PMCID: PMC11825129, DOI: 10.7554/elife.89459.Peer-Reviewed Original ResearchConceptsIon occupancyIon binding sitesTerminal amineSelectivity filterIon densityLow-resolution structureProtein conformationIonsDetergent micellesPotassium channelsToxin blockVoltage-gated potassium channel Kv1.2Non-conductingStructureVoltage-gated potassium channelsPotassium channel Kv1.2Kv1.2 potassium channelChannel's outer mouthBinding sitesAminesCarbonyl
2023
Efficient O -demethylation of lignin-derived aromatic compounds under moderate conditions
Wang Y, Chen M, Yang Y, Ralph J, Pan X. Efficient O -demethylation of lignin-derived aromatic compounds under moderate conditions. RSC Advances 2023, 13: 5925-5932. PMID: 36816077, PMCID: PMC9936356, DOI: 10.1039/d3ra00245d.Peer-Reviewed Original ResearchElectron-withdrawing substituentsCarbonyl groupAlkyl hydroxyl groupsModerate conditionsElectron-donatingMethoxy groupAlkyl hydroxylationHydroxyl groupsStable intermediateLithium bromideAromatic compoundsAromaticsSubstituentsLignin depolymerizationAromatic chemicalsO-demethylationCarbonylLignin-derived aromaticsAlkylationEfficient methodBromideLignin-derived aromatic compoundsHydroxylCompoundsIntermediateSelective Methane Oxidation by Heterogenized Iridium Catalysts
Li H, Fei M, Troiano J, Ma L, Yan X, Tieu P, Yuan Y, Zhang Y, Liu T, Pan X, Brudvig G, Wang D. Selective Methane Oxidation by Heterogenized Iridium Catalysts. Journal Of The American Chemical Society 2023, 145: 769-773. PMID: 36594824, DOI: 10.1021/jacs.2c09434.Peer-Reviewed Original ResearchConceptsSelective methane oxidationValue-added oxygenatesPrepared catalystIr complexesIr centerOxide supportIridium catalystEasy separationC bondDirect CHImmobilization approachCatalystMethyl migrationOH productionMethane oxidationAcetic acidDirect routeKey stepCHCarbonylationElectrophilicityOxygenatesCarbonylBondsOxidation
2019
Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls
Dongbang S, Shen Z, Ellman J. Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls. Angewandte Chemie 2019, 131: 12720-12724. DOI: 10.1002/ange.201906633.Peer-Reviewed Original ResearchAcyclic Quaternary CentersRelative stereochemistryHomoallylic alcoholsQuaternary centerThree-component strategyBond activationΣ-bondBond additionStereogenic centersCo IIIHigh diastereoselectivityDieneSequential additionThree-componentStereochemistrySubstrate combinationsAlcoholCarbonylAldehydesBondsKetonesDiastereoselectivitySynthesisReactionSynthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls
Dongbang S, Shen Z, Ellman J. Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls. Angewandte Chemie International Edition 2019, 58: 12590-12594. PMID: 31310435, PMCID: PMC6713593, DOI: 10.1002/anie.201906633.Peer-Reviewed Original ResearchConceptsAcyclic Quaternary CentersRelative stereochemistryHomoallylic alcoholsQuaternary centerH bond activationThree-component strategyBond activationBond additionΣ-bondEfficient COStereogenic centersHigh diastereoselectivitySequential additionDieneThree-componentStereochemistrySubstrate combinationsAlcoholAldehydesCarbonylBondsKetonesDiastereoselectivitySynthesisCO
2016
Transition-Metal-Catalyzed C–H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds
Hummel JR, Boerth JA, Ellman JA. Transition-Metal-Catalyzed C–H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds. Chemical Reviews 2016, 117: 9163-9227. PMID: 27936637, PMCID: PMC5468517, DOI: 10.1021/acs.chemrev.6b00661.Peer-Reviewed Original ResearchH bond additionΠ bondsBond additionH bondsHigh functional group compatibilityFunctional group compatibilityCascade reaction sequenceDiversity of transformationsDifferent heterocyclicTransition metalsGroup compatibilityCarbocyclic productsCatalyzed CReaction sequenceBondsIminesCarbonylRapid accessWaste byproductDiverse arrayCatalystHeterocyclicProductsPowerful approachTypes of products
1999
General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
Lee A, Huang L, Ellman J. General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors. Journal Of The American Chemical Society 1999, 121: 9907-9914. DOI: 10.1021/ja992009a.Peer-Reviewed Original ResearchNucleophilic displacementGeneral solid-phase methodExpedient solid-phase synthesisSolid-phase synthesisSolid-phase methodFirst general methodKetone productsAvailable precursorsSolid supportΑ-stereocenterKetone carbonylCysteine protease inhibitorsOverall yieldFurther transformationDiverse functionalitiesSynthesis approachHydrazones 8ThiolatesCarboxylateChloromethyl ketoneCarbonylGeneral methodKetonesAminesMercaptomethyl
1986
Structure of lysine adducts with 16α-hydroxyestrone and cortisol
Bucala R, Ulrich P, Chait B, Bencsath F, Cerami A. Structure of lysine adducts with 16α-hydroxyestrone and cortisol. The Journal Of Steroid Biochemistry And Molecular Biology 1986, 25: 127-133. PMID: 3091937, DOI: 10.1016/0022-4731(86)90291-8.Peer-Reviewed Original ResearchConceptsSchiff baseReduced Schiff baseStructure of lysineCovalent addition productsPresence of NaCNBH3Schiff base adductsHeyns rearrangementNucleophilic additionAddition productsBase adductsEpsilon-amino groupLysine derivativesStructural analysisAdductsLysine residuesReactionNaCNBH3MoietyCarbonylAminesCompoundsSynthesisMoleculesProductsLysine
1968
The oxidation of tungsten carbonyl in carbon tetrachloride
Silverman R, Olofson R. The oxidation of tungsten carbonyl in carbon tetrachloride. Chemical Communications 1968, 1313-1313. DOI: 10.1039/c19680001313.Peer-Reviewed Original Research
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