2022
C–H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity
Brandes DS, Ellman JA. C–H bond activation and sequential addition to two different coupling partners: a versatile approach to molecular complexity. Chemical Society Reviews 2022, 51: 6738-6756. PMID: 35822540, PMCID: PMC9364435, DOI: 10.1039/d2cs00012a.Peer-Reviewed Original ResearchConceptsAddition reactionH bondsMolecular complexityAtom-economical reactionH bond activationH bond additionSingle reaction sequenceBond activationΣ-bondBond additionCarbonyl compoundsΠ bondsΠ-systemType of functionalityStereochemical controlCoupling partnersMild conditionsSubsequent couplingReaction sequenceVersatile approachDifferent coupling partnersReagentsSequential additionMore complex structuresReaction
2019
Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls
Dongbang S, Shen Z, Ellman J. Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls. Angewandte Chemie 2019, 131: 12720-12724. DOI: 10.1002/ange.201906633.Peer-Reviewed Original ResearchAcyclic Quaternary CentersRelative stereochemistryHomoallylic alcoholsQuaternary centerThree-component strategyBond activationΣ-bondBond additionStereogenic centersCo IIIHigh diastereoselectivityDieneSequential additionThree-componentStereochemistrySubstrate combinationsAlcoholCarbonylAldehydesBondsKetonesDiastereoselectivitySynthesisReactionSynthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls
Dongbang S, Shen Z, Ellman J. Synthesis of Homoallylic Alcohols with Acyclic Quaternary Centers through CoIII‐Catalyzed Three‐Component C−H Bond Addition to Internally Substituted Dienes and Carbonyls. Angewandte Chemie International Edition 2019, 58: 12590-12594. PMID: 31310435, PMCID: PMC6713593, DOI: 10.1002/anie.201906633.Peer-Reviewed Original ResearchConceptsAcyclic Quaternary CentersRelative stereochemistryHomoallylic alcoholsQuaternary centerH bond activationThree-component strategyBond activationBond additionΣ-bondEfficient COStereogenic centersHigh diastereoselectivitySequential additionDieneThree-componentStereochemistrySubstrate combinationsAlcoholAldehydesCarbonylBondsKetonesDiastereoselectivitySynthesisCO
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