General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors
Lee A, Huang L, Ellman J. General Solid-Phase Method for the Preparation of Mechanism-Based Cysteine Protease Inhibitors. Journal Of The American Chemical Society 1999, 121: 9907-9914. DOI: 10.1021/ja992009a.Peer-Reviewed Original ResearchNucleophilic displacementGeneral solid-phase methodExpedient solid-phase synthesisSolid-phase synthesisSolid-phase methodFirst general methodKetone productsAvailable precursorsSolid supportΑ-stereocenterKetone carbonylCysteine protease inhibitorsOverall yieldFurther transformationDiverse functionalitiesSynthesis approachHydrazones 8ThiolatesCarboxylateChloromethyl ketoneCarbonylGeneral methodKetonesAminesMercaptomethyl
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