2023
Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation
Meyer K, Lammers N, Bugaj L, Garcia H, Weiner O. Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation. Nature Communications 2023, 14: 6929. PMID: 37903793, PMCID: PMC10616176, DOI: 10.1038/s41467-023-42643-2.Peer-Reviewed Original ResearchConceptsCell fateYAP levelsControlling gene activityCell fate analysisPluripotency regulators Oct4Stem cell fateEffector genesTranscriptional regulationGene activationControl pluripotencyYAP activityNative dynamicsCellular differentiationRegulators Oct4Developmental decision-makingControl proliferationMolecular logicCell behaviorYAPFate analysisDynamic decoderOptogenetic controlOct4 expressionCellsFate
2020
YAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells
Hartman AA, Scalf SM, Zhang J, Hu X, Chen X, Eastman AE, Yang C, Guo S. YAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells. Stem Cell Reports 2020, 14: 730-743. PMID: 32243844, PMCID: PMC7160372, DOI: 10.1016/j.stemcr.2020.03.006.Peer-Reviewed Original ResearchConceptsPluripotency inductionCell typesMouse somatic cellsMultiple stem cell typesHeterologous cell typesStem cell typesPluripotent stem cellsEarly embryogenesisSomatic cellsDistinct functionsMouse cellsMatricellular proteinYAPRecombinant CYR61Stem cellsAutonomous roleCyr61Specific cellsBystander cellsProteinCellsInductionPluripotencyEmbryogenesisControl mechanismsBile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration
Meyer K, Morales‐Navarrete H, Seifert S, Wilsch‐Braeuninger M, Dahmen U, Tanaka E, Brusch L, Kalaidzidis Y, Zerial M. Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 2020, 16: msb198985. PMID: 32090478, PMCID: PMC7036714, DOI: 10.15252/msb.20198985.Peer-Reviewed Original ResearchConceptsActin cytoskeletonActive YAPMechanisms of organ size controlF-actin-rich regionsTranscriptional co-activator YAPSurface of hepatocytesOrgan size controlCo-activator YAPApical surface of hepatocytesApical surfaceF-actinAcid fluctuationsHippo signalingTissue homeostasisBile acidsMouse liver regenerationBile acid overloadYAPMechano-sensory systemsCytoskeletonAcid overloadActinBile canalicular networkLevels of bile acidsCanalicular network
2019
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Journal Of Clinical Investigation 2019, 129: 4863-4874. PMID: 31408443, PMCID: PMC6819111, DOI: 10.1172/jci127692.Peer-Reviewed Original ResearchConceptsPP2A regulatory subunit B55αTranscription factor YAPActive PDEComplex assemblyAdapter rolePDE4D5B55αIntegrin α5EC phenotypeCell functionInflammatory signalingAthero-prone regionsActivationComplexesPP2AInflammatory activationWidespread consequencesDephosphorylationProteomicsVascular remodelingPlaque sizeAtherosclerotic plaque sizeSignalingYAPRegulates
2017
Drug development against the hippo pathway in mesothelioma
Woodard GA, Yang YL, You L, Jablons DM. Drug development against the hippo pathway in mesothelioma. Translational Lung Cancer Research 2017, 6: 335-342. PMID: 28713678, PMCID: PMC5504108, DOI: 10.21037/tlcr.2017.06.02.Peer-Reviewed Original ResearchYAP/TEADCell pathwaysCell contact inhibitionStem cell populationCancer stem cell populationStem cell pathwaysTumor suppressor geneDownstream YAPHippo pathwaySuppressor geneContact inhibitionYAP inhibitorConventional cytotoxic drugsCell populationsMalignant pleural mesotheliomaPathwayDrug developmentTumor resistanceUltimate targetTEADGenesOncogeneYAPEffective chemotherapy drugsChemotherapy drugs
2015
Endosomal regulation of contact inhibition through the AMOT:YAP pathway
Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Molecular Biology Of The Cell 2015, 26: 2673-2684. PMID: 25995376, PMCID: PMC4501364, DOI: 10.1091/mbc.e15-04-0224.Peer-Reviewed Original ResearchConceptsEndosomal membranesYAP activitySubconfluent cellsOrgan growth controlTranscription coactivator YesPhosphorylation-dependent regulationIntegral membrane proteinsConfluent cellsAmot proteinsEndosomal regulationContact-mediated inhibitionCytoplasmic domainEndotubinMembrane proteinsOvergrowth phenotypeInduces translocationAngiomotinYAP interactionDirect bindingGrowth controlContact inhibitionFamily membersCell growthYAPYAP pathway
2014
CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMA
Shah S, Tippens N, Park J, Mohyeldin A, Vela G, Levchenko A, Quinones-Hinojosa A. CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMA. Neuro-Oncology 2014, 16: v57-v58. PMCID: PMC4217989, DOI: 10.1093/neuonc/nou242.31.Peer-Reviewed Original ResearchCell migration pathwaysMechanism of YAPYAP-dependent mechanismsAbility of cellsDependent signaling mechanismRole of YAPFunction of YAPSmall Rho GTPaseExtracellular cuesTranscriptional regulatorsRho GTPaseSingle-cell mannerMolecular networksIntracellular signalingSignaling mechanismCell mannerCell polarizationCell migrationIndividual cellsCritical modulatorAggressive cancerYAPInvasive behaviorPoor patient prognosisYAP expressionEffect of Pulsatile and Continuous Flow on Yes-Associated Protein
Chitragari G, Shalaby SY, Sumpio BJ, Sumpio BE. Effect of Pulsatile and Continuous Flow on Yes-Associated Protein. International Journal Of Angiology 2014, 23: 183-186. PMID: 25317030, PMCID: PMC4169103, DOI: 10.1055/s-0034-1376865.Peer-Reviewed Original ResearchHuman umbilical vein endothelial cellsContinuous forward flowTotal YAPPhosphorylated YAPEndothelial cellsPathogenesis of atherosclerosisEffects of pulsatileRole of YAPUmbilical vein endothelial cellsVein endothelial cellsYes-Associated ProteinMild decreaseFlow chamber systemFibronectin-coated glass slidesParallel plate flow chamber systemSignificant decreaseLonger durationSignificant differencesAtherosclerosisDifferential effectsLevel of phosphorylationForward flowMinutesYAPPFF
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