2023
Identification of genes influencing the evolution of Escherichia coli ST372 in dogs and humans
Elankumuran P, Browning G, Marenda M, Kidsley A, Osman M, Haenni M, Johnson J, Trott D, Reid C, Djordjevic S. Identification of genes influencing the evolution of Escherichia coli ST372 in dogs and humans. Microbial Genomics 2023, 9: mgen000930. PMID: 36752777, PMCID: PMC9997745, DOI: 10.1099/mgen.0.000930.Peer-Reviewed Original ResearchConceptsPopulation structureIdentification of genesWhole genome sequencesPropanediol utilization (pdu) operonGenomic traitsAccessory genomeCanine sourcesBioinformatics analysisUtilization operonPhylogenetic clustersGlobal collectionDistinct populationsVirulence genesOperonGenesDominant hostSequence typesSequenceExtraintestinal infectionsPhylogenyCladeGenomeLineagesHumansTraits
2020
The whale shark genome reveals how genomic and physiological properties scale with body size
Weber J, Park S, Luria V, Jeon S, Kim H, Jeon Y, Bhak Y, Jun J, Kim S, Hong W, Lee S, Cho Y, Karger A, Cain J, Manica A, Kim S, Kim J, Edwards J, Bhak J, Church G. The whale shark genome reveals how genomic and physiological properties scale with body size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20662-20671. PMID: 32753383, PMCID: PMC7456109, DOI: 10.1073/pnas.1922576117.Peer-Reviewed Original ResearchConceptsWhale shark genomeShark genomeBody sizeGene lengthWhale sharksLarge-scale comparative genomic analysisLong neural genesMetazoan genome architectureSlow evolutionary rateComparative genomics approachLonger gene lengthComparative genomic analysisMultiple genetic featuresCodon adaptation indexMetabolic rateAverage geneGenome architectureNeurodegeneration genesEvolutionary ratesMost genomesGenomic approachesGenomic traitsNeural genesGenome featuresBiological traits
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