2020
The whale shark genome reveals how genomic and physiological properties scale with body size
Weber J, Park S, Luria V, Jeon S, Kim H, Jeon Y, Bhak Y, Jun J, Kim S, Hong W, Lee S, Cho Y, Karger A, Cain J, Manica A, Kim S, Kim J, Edwards J, Bhak J, Church G. The whale shark genome reveals how genomic and physiological properties scale with body size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20662-20671. PMID: 32753383, PMCID: PMC7456109, DOI: 10.1073/pnas.1922576117.Peer-Reviewed Original ResearchConceptsWhale shark genomeShark genomeBody sizeGene lengthWhale sharksLarge-scale comparative genomic analysisLong neural genesMetazoan genome architectureSlow evolutionary rateComparative genomics approachLonger gene lengthComparative genomic analysisMultiple genetic featuresCodon adaptation indexMetabolic rateAverage geneGenome architectureNeurodegeneration genesEvolutionary ratesMost genomesGenomic approachesGenomic traitsNeural genesGenome featuresBiological traits
2018
De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria
Redmond SN, MacInnis BM, Bopp S, Bei AK, Ndiaye D, Hartl DL, Wirth DF, Volkman SK, Neafsey DE. De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria. Molecular Biology And Evolution 2018, 35: 1678-1689. PMID: 29722884, PMCID: PMC5995194, DOI: 10.1093/molbev/msy059.Peer-Reviewed Original ResearchConceptsDe novo mutationsEvolutionary ratesSlow evolutionary rateNovo mutationsComplex life cycleSlow generation timeLow-complexity regionsGenomic regionsLarge genomesGenomic epidemiology approachReintroduction scenariosCombination of sequencingP. falciparumViral speciesMutation rateClonal lineagesGenomeMutation studiesLibrary preparationIdentical parasitesGeneration timeBacterial pathogensMalaria parasitesMutationsGenomic epidemiology
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