2025
Non-neoplastic Trophoblastic Proliferations
Hui P. Non-neoplastic Trophoblastic Proliferations. 2025, 105-115. DOI: 10.1007/978-3-031-83545-2_8.Peer-Reviewed Original ResearchExaggerated placental site reactionPlacental site noduleAtypical placental site noduleIntermediate trophoblastTrophoblastic tumorNon-trophoblastic neoplasmsGestational trophoblastic tumorsSquamous cell carcinomaNon-neoplastic conditionsCell carcinomaSite reactionsNeoplastic counterpartsCytologic featuresProliferative lesionsIncidental findingImplantation sitesImaging studiesTrophoblastConcurrent gestationTumorLesionsChorion typePlacental Trophoblast
Hui P. Placental Trophoblast. 2025, 47-54. DOI: 10.1007/978-3-031-83545-2_4.Peer-Reviewed Original ResearchIntermediate trophoblastChorionic villiChorionic-type intermediate trophoblastImplantation site intermediate trophoblastsExtravillous intermediate trophoblastFetal-maternal exchangeMultinucleated syncytiotrophoblast layerTrophoblast cell layerLayers of trophoblastPattern of cytokeratinsSubtypes of trophoblastsFetal circulationTrophoblast columnsBlastocyst implantationPlacental trophoblastsSyncytiotrophoblast layerUmbilical cordVillous trophoblastExtravillous trophoblastImmunohistochemical markersCytotrophoblast layerPlacenta formationTrophoblast cellsTrophoblastMesenchymal core
2024
EV016/#559 Preclinical activity of datopotamab deruxtecan, a novel trophoblast cell-surface antigen 2 (TROP2) directed antibody-drug conjugate targeting TROP2 in high grade serous ovarian carcinoma
Mcnamara B, Greenman M, Bellone S, Demirkiran C, Mutlu L, Hartwich T, Yang-Hartwich Y, Ratner E, Schwartz P, Santin A. EV016/#559 Preclinical activity of datopotamab deruxtecan, a novel trophoblast cell-surface antigen 2 (TROP2) directed antibody-drug conjugate targeting TROP2 in high grade serous ovarian carcinoma. International Journal Of Gynecological Cancer 2024, 34: a91. DOI: 10.1136/ijgc-2024-igcs.135.Peer-Reviewed Original ResearchNoninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study
Bellair M, Amaral E, Ouren M, Roark C, Kim J, O'Connor A, Soriano A, Schindler M, Wapner R, Stone J, Tavella N, Merriam A, Perley L, Breman A, Beaudet A. Noninvasive single‐cell‐based prenatal genetic testing: A proof of concept clinical study. Prenatal Diagnosis 2024, 44: 304-316. PMID: 38411249, DOI: 10.1002/pd.6529.Peer-Reviewed Original ResearchConceptsNoninvasive prenatal genetic testingLow-risk pregnanciesConcept clinical studyCopy number analysisPrenatal genetic testingNext-generation sequencingPlacental mosaicismMaternal bloodAneuploidy resultsMeasures of test performanceCK stainingCVS casesClinical studiesGenetic testingNucleated cellsTrophoblastRed cellsNumber analysisPregnancyBloodDeletions/duplicationsAneuploidyDeletionAmniocentesisCells
2022
Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation
Wang M, Silva T, Toothaker JM, McCourt BT, Shugrue C, Desir G, Gorelick F, Konnikova L. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation. Scientific Reports 2022, 12: 4953. PMID: 35322081, PMCID: PMC8943056, DOI: 10.1038/s41598-022-08817-6.Peer-Reviewed Original ResearchConceptsPlacental tissuePlacental villiHofbauer cellsPlacental developmentEndogenous productionAnti-inflammatory milieuPotential roleHuman placental tissueFull-term placentaPlacental factorsFetal interfaceDecidual samplesPlacental functionChorionic plateImmunoreactive cellsPlacental samplesHuman gestationRenalaseBulk RNA sequencingHuman placentaPlacentaQuantification of immunohistochemistryProtein levelsTrophoblastTransmission of nutrients
2019
In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines.
Kisanga EP, Tang Z, Guller S, Whirledge S. In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines. Journal Of Visualized Experiments 2019 PMID: 30907868, DOI: 10.3791/58942.Peer-Reviewed Original ResearchConceptsCell movementCell migrationHuman first trimester trophoblast cell lineFirst trimester trophoblast cell lineIntrauterine growth restrictionCell linesTrophoblast cell linePregnancy disordersEarly pregnancyGrowth restrictionMaternal vasculatureTrophoblast migrationMigratory capacityPlacental developmentPotential mechanismsCellular changesVitro assaysInvasionTrophoblastProliferationThorough examinationMigrationAssaysIndividual factorsPregnancy
2018
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
Sozen B, Amadei G, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover D, Zernicka-Goetz M. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nature Cell Biology 2018, 20: 979-989. PMID: 30038254, DOI: 10.1038/s41556-018-0147-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell DifferentiationCell LineCell LineageCell MovementCoculture TechniquesEmbryo, MammalianEndodermEpithelial-Mesenchymal TransitionGastrulationGene Expression Regulation, DevelopmentalGestational AgeMiceMouse Embryonic Stem CellsPhenotypeTranscriptomeTrophoblastsConceptsStem cell typesEpithelial-mesenchymal transitionStem cellsExtra-embryonic compartmentCell typesTrophoblast stem cellsEndoderm stem cellsEmbryonic stem cellsMammalian embryosSpatial transcriptomic analysisTrophoblastGene expression patternsGerm lineMiceGastrulating embryosEmbryo-like structures
2012
Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis
Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER, Abrahams VM. Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis. American Journal Of Reproductive Immunology 2012, 69: 449-453. PMID: 23279063, PMCID: PMC3620725, DOI: 10.1111/aji.12065.Peer-Reviewed Original ResearchConceptsIL-6 secretionTrophoblast apoptosisTLR2 coreceptorsHuman trophoblast cell lineIntrauterine bacterial infectionFirst-trimester human trophoblast cell lineThird-trimester human placental tissueHuman placental tissueTrophoblast cell linePositive bacterial componentsTLR10 expressionPreterm laborThird trimesterCaspase-3 activityIL-6TLR2 activationPlacental tissuePlacental apoptosisBacterial infectionsTLR10Bacterial componentsBacterial peptidoglycanTrophoblastCell linesApoptosisToll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy
Schatz F, Kayisli UA, Vatandaslar E, Ocak N, Guller S, Abrahams VM, Krikun G, Lockwood CJ. Toll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy. American Journal Of Reproductive Immunology 2012, 68: 146-153. PMID: 22564191, PMCID: PMC3395732, DOI: 10.1111/j.1600-0897.2012.01148.x.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Interstitial trophoblastDecidual cellsDanger signalsToll-like receptor 4 expressionFirst trimester decidual cellsReceptor 4 expressionHuman pregnancyElective terminationNormal deliveryDecidua parietalisReceptor 4Luteal phaseStromal cellsGram-negative bacteriaSerial sectionsTrophoblastPrimary targetCellsClose contactEndometriumPregnancyHScoreGestationCytokeratin814: Evidence that endoglin and transforming growth factor-beta (TGFβ) participate in epithelial-to-mesenchymal transition (EMT) of extravillous trophoblasts in placenta accreta
Duzyj C, Buhimschi I, Laky C, Cozzini G, Zhao G, Wehrum M, Pettker C, Abdel-Razeq S, Buhimschi C. 814: Evidence that endoglin and transforming growth factor-beta (TGFβ) participate in epithelial-to-mesenchymal transition (EMT) of extravillous trophoblasts in placenta accreta. American Journal Of Obstetrics And Gynecology 2012, 206: s357. DOI: 10.1016/j.ajog.2011.10.832.Peer-Reviewed Original ResearchPlacental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia
Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.Peer-Reviewed Original ResearchConceptsPlacental protein 13Spiral arteriolesImmune cellsDecidual zoneProtein 13Decidual spiral arteriolesMaternal immune cellsWeeks of gestationElective pregnancy terminationHuman placental lactogenMaternal spiral arteriolesDecidual necrosisPregnancy terminationT cellsImmunohistochemical analysisDecidual veinsIntervillus spacePlacental lactogenInvasive trophoblastApoptosis markersPP13Chorionic villiNecrosisTrophoblastArterioles
2011
Tumor-Like Trophoblastic Conditions
Hui P. Tumor-Like Trophoblastic Conditions. Current Clinical Pathology 2011, 147-159. DOI: 10.1007/978-1-61779-394-3_10.Peer-Reviewed Original ResearchPlacental site nodulePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastExaggerated placental site reactionNon-trophoblastic neoplasmsSquamous cell carcinomaPrior pregnancyCell carcinomaSite reactionsIncidental findingProliferative lesionsNeoplastic counterpartsImplantation sitesCytological featuresLesionsTumorsTrophoblastConcurrent gestationReactive conditionsClinicopathologicallyPregnancyReactive processCarcinomaPartial Hydatidiform Mole
Buza N. Partial Hydatidiform Mole. Current Clinical Pathology 2011, 77-90. DOI: 10.1007/978-1-61779-394-3_5.Peer-Reviewed Original ResearchGestational trophoblastic neoplasiaGestational trophoblastic diseasePersistent gestational trophoblastic diseasePartial Hydatidiform MoleClinical presentationTrophoblastic neoplasiaSubsequent riskTrophoblastic diseaseNonneoplastic proliferationTriploid gestationsVillous trophoblastDistinct subtypesTrophoblastic hyperplasiaHydatidiform MolePartial hydatidiformChorionic villiSignificant differencesHydatidiformGestationHyperplasiaNeoplasiaSubtypesDiseaseTrophoblastHistomorphologyHormonal Regulation of Galectin 3 in Trophoblasts and Its Effects on Endometrium
Yang H, Taylor HS, Lei C, Cheng C, Zhang W. Hormonal Regulation of Galectin 3 in Trophoblasts and Its Effects on Endometrium. Reproductive Sciences 2011, 18: 1118-1127. PMID: 21555510, DOI: 10.1177/1933719111407212.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinGal-3RL95-2 cellsEmbryo implantationEndometrial cellsBeWo cellsGalectin-3Endometrial cell proliferationCell proliferationEndometrial epithelial cellsHormonal regulationExogenous Gal-3Chorionic gonadotropinTrophoblastic cellsVivo modelEndometriumExtracellular effectsIntegrin β3Apoptotic rateProapoptotic effectsEpithelial cellsImplantationIntegrin β1TrophoblastCells
2009
ORIGINAL ARTICLE: Regulation of Nod1 and Nod2 in First Trimester Trophoblast Cells
Mulla MJ, Yu AG, Cardenas I, Guller S, Panda B, Abrahams VM. ORIGINAL ARTICLE: Regulation of Nod1 and Nod2 in First Trimester Trophoblast Cells. American Journal Of Reproductive Immunology 2009, 61: 294-302. PMID: 19260860, DOI: 10.1111/j.1600-0897.2009.00694.x.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBenzamidesCells, CulturedCytokinesDiaminopimelic AcidFemaleGene Expression Regulation, DevelopmentalHumansLipopolysaccharidesNF-kappa BNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinPregnancyPregnancy Trimester, FirstSequence DeletionSignal TransductionThiazolesToll-Like Receptor 4TransgenesTrophoblastsConceptsFirst trimester trophoblast cellsTrophoblast cellsExpression of NOD1Cytoplasmic pattern recognition receptorsProduction of cytokinesNOD2 mRNA expressionPattern recognition receptorsNOD2 expressionCytokine responsesInflammatory responseNOD2 activationNOD1 activationNFkappaB inhibitorRecognition receptorsNOD1Nod1 stimulationNOD2Bacterial lipopolysaccharideMRNA expressionTLR4LipopolysaccharideNFkappaB pathwayRT-PCRBacterial peptidesTrophoblast
2008
IFPA Meeting 2008 Workshops Report
Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA Meeting 2008 Workshops Report. Placenta 2008, 30: 4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.Peer-Reviewed Original ResearchConceptsPlacental mesenchymal stem cellsIFPA annual meetingPlacental toxicologyPlacental pathologyPlacental transportTrophoblast subpopulationsMesenchymal stem cellsThemed workshopsStem cellsPlacentationFatty acidsInvasionWorkshop reportAnnual MeetingReportComparative placentationNeoplasiaPathologyTrophoblastImmunology
2006
Trophoblast Cells as Immune Regulators
Mor G, Abrahams V. Trophoblast Cells as Immune Regulators. Medical Intelligence Unit 2006, 215-228. PMCID: PMC7120375, DOI: 10.1007/0-387-34944-8_19.Peer-Reviewed Original Research
2004
First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis
Abrahams VM, Straszewski-Chavez S, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004, 10: 55-63. PMID: 14665707, DOI: 10.1093/molehr/gah006.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsImmune privilegeTrophoblast cellsFas/Fas ligand (FasL) apoptotic pathwayMaternal immune recognitionMaternal immune systemImmune cell apoptosisSecretion of FasLT cell deathPaternal alloantigensAllograft rejectionNormal pregnancyPeripheral toleranceImmune recognitionImmune systemRelease of microvesiclesFas ligandCell apoptosisVivo studiesFasLMembrane-associated expressionTrophoblastIntracellular FasLApoptotic pathwayDeath
2003
Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes
Geirsson A, Lynch RJ, Paliwal I, Bothwell AL, Hammond GL. Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes. Biochemical And Biophysical Research Communications 2003, 301: 718-724. PMID: 12565840, DOI: 10.1016/s0006-291x(03)00028-7.Peer-Reviewed Original ResearchConceptsClass II expressionCIITA expressionPromoter IIIClassical MHC antigensMHC class IICIITA promoter IIIAllograft toleranceMHC antigensMurine B lymphocytesFunctional assessmentB lymphocytesClass III-AkIII activityPromoter-reporter constructsTrophoblastCH27BlotTransient transfectionExpressionNorthern blotNegative trans-acting factorsNoncoding RNAsSuppressionTrans-acting factors
1992
Differentiation of the Trophoblast
Kliman H, Feinberg R. Differentiation of the Trophoblast. 1992, 3-25. DOI: 10.1007/978-3-642-84385-3_1.Peer-Reviewed Original ResearchOuter cell layersHuman trophoblastsTrophoblastic cell columnsDifferentiation pathwayUnique cellsDifferentiated functionsDifferentiation behaviorUndifferentiated cytotrophoblastsGestational ageIntermediate trophoblastSubsequent functionVillous syncytiotrophoblastCell columnVillous cytotrophoblastsHuman placentaTrophoblastCytotrophoblastsCell layerControl mechanismsBiologyDifferentiationPathwayBlastocystsPlacentaSyncytiotrophoblast
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