2022
Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor
Manavella D, McNamara B, Harold J, Bellone S, Hartwich T, Yang-Hartwich Y, Mutlu L, Zipponi M, Demirkiran C, Verzosa M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Dottino P, Choi J, Alexandrov L, Buza N, Hui P, Santin A. Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor. Gynecologic Oncology 2022, 169: 98-105. PMID: 36525930, PMCID: PMC9925406, DOI: 10.1016/j.ygyno.2022.12.003.Peer-Reviewed Original ResearchConceptsHomologous recombination deficiencyCS cell linesCell linesWestern blotKinase inhibitorsOverall animal survivalProtein expressionDose-dependent increaseDose-dependent inhibitionCarcinosarcoma cell lineTumor growth inhibitionCaspase-3 expressionEndometrioid histologyAggressive malignancyUterine carcinosarcomaCS patientsPreclinical activityClinical trialsEpithelial componentAnimal survivalXenograftsApoptosis markersRecombination deficiencyP-ATRP-Chk1
2019
Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice
Nakandakari S, Muñoz V, Kuga G, Gaspar R, Sant'Ana M, Pavan I, da Silva L, Morelli A, Simabuco F, da Silva A, de Moura L, Ropelle E, Cintra D, Pauli J. Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice. Brain Behavior And Immunity 2019, 79: 284-293. PMID: 30797044, DOI: 10.1016/j.bbi.2019.02.016.Peer-Reviewed Original ResearchConceptsHigh-fat dietYoung miceShort-term HFD feedingMice fed high-fat dietFed high-fat dietHippocampus of miceER stressDisease developmentShort-term consumptionAlzheimer's disease developmentPotential molecular mechanismsHOMA-IRHFD feedingAD markersMicroglial cellsAD pathogenesisRisk factorsInflammatory signalsDiet modulatesΒ-amyloidCleaved caspase3HippocampusApoptosis markersHigh expressionMice
2014
Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death
Scuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.Peer-Reviewed Original ResearchConceptsNAP treatmentRetinas of STZSingle intraocular injectionCaspase-3 expression levelsRetinal degenerative diseasesMAPK/ERK pathwayPhosphatidylinositol-3-kinase/Akt pathwayMitogen-activated protein kinase/extracellular signal-regulated protein kinaseDiabetes inductionDiabetic injuryDiabetic retinaSTZ injectionNeuroprotective effectsDiabetic modelIntraocular injectionPotent neuroprotectionDiabetic retinopathyVivo streptozotocinRetinal expressionProtein kinase/extracellular signal-regulated protein kinaseAmino acid peptideKinase/Akt pathwayP-AktP-ERKApoptosis markers
2012
Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia
Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.Peer-Reviewed Original ResearchConceptsPlacental protein 13Spiral arteriolesImmune cellsDecidual zoneProtein 13Decidual spiral arteriolesMaternal immune cellsWeeks of gestationElective pregnancy terminationHuman placental lactogenMaternal spiral arteriolesDecidual necrosisPregnancy terminationT cellsImmunohistochemical analysisDecidual veinsIntervillus spacePlacental lactogenInvasive trophoblastApoptosis markersPP13Chorionic villiNecrosisTrophoblastArterioles
2008
The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men
El-Domyati MM, Al-Din AB, Barakat MT, El-Fakahany HM, Honig S, Xu J, Sakkas D. The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men. Fertility And Sterility 2008, 93: 795-801. PMID: 19062002, DOI: 10.1016/j.fertnstert.2008.10.031.Peer-Reviewed Original ResearchConceptsInfertile varicocele patientsDNA repair markersVaricocele patientsFertile menTesticular germ cellsApoptosis markersRetrospective case-control studyRepair markersHuman testicular germ cellsCase-control studyCell proliferation markersApoptosis marker proteinsGerm cellsTesticular specimensImmunohistochemical stainingMAIN OUTCOMEFertile volunteersInfertile menPatientsProliferation markersAbove markersDeoxyribonucleic acid repairTesticular tissueYoung menMen
1998
Recent advances in endometriosis
Arici A, Pehlivan T. Recent advances in endometriosis. Current Opinion In Endocrinology Diabetes And Obesity 1998, 5: 330-340. DOI: 10.1097/00060793-199811000-00015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritoneal fluidMaximal pain reliefEndometriosis-associated infertilityEffect of endometriosisChemoattractant protein-1Pathogenesis of endometriosisPain reliefPelvic painIL-10Pathophysiologic mechanismsTreatment optionsEctopic endometriumIL-13Endometrial cellsReproductive outcomesAromatase expressionMild lesionsSide effectsFertility outcomesMatrix metalloproteinasesEndometriosisPeritoneal macrophagesApoptosis markersIntegrin expressionProtein 1
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