2020
Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling
Mortlock RD, Georgia SK, Finley SD. Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling. Cellular And Molecular Bioengineering 2020, 14: 15-30. PMID: 33633812, PMCID: PMC7878662, DOI: 10.1007/s12195-020-00647-8.Peer-Reviewed Original ResearchBeta-cell massBeta cellsInsulin-producing beta cellsReceptor internalizationContext of pregnancyPrimary beta cellsJAK-STATPancreatic beta cellsBeta cell expansionBeta-cell survivalSTAT5 activationProlactin receptor signalingINS-1 cellsGestational diabetesInsulin resistanceReceptor upregulationGlucose homeostasisBiphasic response
2010
A Paradoxical Role for Neutrophils in the Pathogenesis of West Nile Virus
Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgometry R. A Paradoxical Role for Neutrophils in the Pathogenesis of West Nile Virus. The Journal Of Infectious Diseases 2010, 202: 1804-1812. PMID: 21050124, PMCID: PMC3053000, DOI: 10.1086/657416.Peer-Reviewed Original ResearchConceptsWest Nile virusPolymorphonuclear leukocytesWNV infectionNile virusHigh viremiaViral clearanceEarly deathEarly infectionControl groupProtective roleBiphasic responseInnate immunityViral pathogenesisInfectionMiceViremiaPathogenesisParadoxical roleEfficient replicationVirusCXCL1CXCL2ChemokinesCXCR2Neutrophils
2009
Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium
Noren D, Levchenko A, Popel A. Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium. The FASEB Journal 2009, 23: 767.15-767.15. DOI: 10.1096/fasebj.23.1_supplement.767.15.Peer-Reviewed Original ResearchVascular endothelial growth factorIntracellular calciumEndothelial growth factorVasoactive factorsVascular permeabilityCalcium levelsRapid transient increaseBiphasic responseCalcium releaseNitric oxideTransient increaseEndothelial cellsVEGF receptorsGrowth factorVascular structuresEC proliferationCalciumKey regulatorVEGF stimulation
2001
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
Elgoyhen A, Vetter D, Katz E, Rothlin C, Heinemann S, Boulter J. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 3501-3506. PMID: 11248107, PMCID: PMC30682, DOI: 10.1073/pnas.051622798.Peer-Reviewed Original ResearchConceptsHair cellsMechanosensory hair cellsCholinergic receptor functionAgonist-mediated desensitizationHair cell functionAlpha9 nAChREfferent modulationHeteromeric nAChRsAlpha9alpha10 nAChRsPharmacological profileBiphasic responseMammalian vestibularReceptor functionAlpha10 subunitsNAChRsCell functionAlpha9Xenopus laevis oocytesCurrent-voltage relationshipVertebrate hair cellsSubunit geneLaevis oocytesAlpha10CellsAlpha9alpha10
2000
Vasomotor control in arterioles of the mouse cremaster muscle
HUNGERFORD J, SESSA W, SEGAL S. Vasomotor control in arterioles of the mouse cremaster muscle. The FASEB Journal 2000, 14: 197-207. PMID: 10627294, DOI: 10.1096/fasebj.14.1.197.Peer-Reviewed Original ResearchConceptsMouse cremaster muscleVasomotor controlCremaster musclePerivascular sympathetic nerve stimulationAnesthetized C57Bl6 miceMicroiontophoresis of acetylcholineSympathetic nerve stimulationNitro-L-arginineConcentration-dependent vasoconstrictionBlood flow controlCremaster muscle preparationFocal vasoconstrictionVasodilatory responseNerve stimulationTransgenic mouse technologyVasomotor responsesC57BL6 miceCardiovascular functionNormal miceMuscle preparationsArteriolesBiphasic responseIntravital microscopyAcetylcholineVasoconstriction
1991
Role of chloride ions in liver cell volume regulation
Haddad P, Beck J, Boyer J, Graf J. Role of chloride ions in liver cell volume regulation. American Journal Of Physiology 1991, 261: g340-g348. PMID: 1872402, DOI: 10.1152/ajpgi.1991.261.2.g340.Peer-Reviewed Original ResearchConceptsRegulatory volume decreaseM omegaLiver cellsSingle isolated rat hepatocytesBiphasic responseHypotonic stressInitial hyperpolarizationPl/minIsolated rat hepatocytesGradual depolarizationCell volume regulationExternal ClRole of C1Hypotonic swellingVolume regulationMembrane potentialFacilitated releaseRat hepatocytesCellsMinVolume decreaseCell volumeInitial volumeInitial rateLiver
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