2025
How Do Patient Outcomes in Mechanical Thrombectomy for Large-Core Stroke Vary Based on Neuroimaging Modalities Used for Patient Selection? A Multicenter Multinational Study
Alwakaa O, Abo Kasem R, Ramirez-Velandia F, Wadhwa A, Han K, Levitt M, Alaraj A, Jabbour P, Kim J, Howard B, Alawieh A, Wolfe S, Starke R, Psychogios M, Shaban A, Goyal N, Dye J, Ezzeldin M, Yoshimura S, Sconzo D, Filo J, Pettersson S, Fiorella D, Tanweer O, Romano D, Navia P, Cuellar H, Fragata I, Polifka A, Mascitelli J, Osbun J, Siddiqui F, Moss M, Limaye K, Mokin M, Matouk C, Park M, Brinjikji W, Daglioglu E, Williamson R, Altschul D, Maier I, Crosa R, Gory B, Grandhi R, Paul A, Kan P, Casagrande W, Chowdhry S, Stiefel M, Rai A, Spiotta A, Taussky P, Ogilvy C, Granstein J. How Do Patient Outcomes in Mechanical Thrombectomy for Large-Core Stroke Vary Based on Neuroimaging Modalities Used for Patient Selection? A Multicenter Multinational Study. Translational Stroke Research 2025, 1-15. PMID: 40900221, DOI: 10.1007/s12975-025-01378-6.Peer-Reviewed Original ResearchAcute ischemic strokeSymptomatic ICH rateCT perfusionPropensity score matchingIntracerebral hemorrhageSymptomatic ICHEndovascular thrombectomyBalanced cohortAnterior circulation acute ischemic strokeLarge-vessel occlusion acute ischemic strokeSymptomatic intracerebral hemorrhageIntracerebral hemorrhage ratesCohort of patientsMTICI 2cIntracerebral hemorrhage incidencePatient selectionClinical outcomesFunctional outcome measuresMTICI scoreInfarct volumeNCCTPatient populationPrimary outcomeMechanical thrombectomySecondary outcomes
2024
Intravenous Thrombolysis in Patients With Cervical Artery Dissection
Shu L, Akpokiere F, Mandel D, Field T, Leon Guerrero C, Henninger N, Muppa J, Affan M, Haq Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, López-Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy Rivas R, Aziz Y, Mistry E, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Garcia J, Muddasani V, de Havenon A, Sanchez S, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Krupka D, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Tountopoulou A, Tentolouris-Piperas V, Martinez-Marino M, Carrasco Wall V, Indraswari F, El Jamal S, Liu S, Zhou M, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Wangqin R, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Intravenous Thrombolysis in Patients With Cervical Artery Dissection. Neurology 2024, 103: e209843. PMID: 39298709, PMCID: PMC11415265, DOI: 10.1212/wnl.0000000000209843.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke symptomsCervical artery dissectionFunctional independenceIntravenous thrombolysisIschemic stroke symptomsStroke symptomsArtery dissectionIncidence of symptomatic intracranial hemorrhageIschemic strokeSymptomatic intracranial hemorrhageSuspected ischemic strokeClass III evidenceMedian ageSymptomatic ICHIntracranial hemorrhageSecondary analysisGuideline recommendationsICH riskIII evidenceFunctional outcomesPatientsThrombolysisCeADYoung adultsDissectionThe effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy.
Elawady S, Kasem R, Matsukawa H, Cunningham C, Sowlat M, Nawabi N, Orscelik A, Venegas J, Isidor J, Loulida H, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Al Kasab S. The effect of intravenous thrombolysis in stroke patients with unsuccessful thrombectomy. Interventional Neuroradiology 2024, 15910199241279009. PMID: 39262342, PMCID: PMC11559907, DOI: 10.1177/15910199241279009.Peer-Reviewed Original ResearchAcute ischemic stroke patientsLarge vessel occlusionAcute ischemic strokeIntracranial hemorrhageBenefit of intravenous thrombolysisMechanical thrombectomyIntravenous thrombolysisMT alone groupAlone groupMT groupSecondary outcomesAnterior circulation large vessel occlusionSymptomatic intracranial hemorrhageEffect of intravenous thrombolysisIVT + MTIntravenous thrombolysis prior to MTPropensity score matchingMedian ageSymptomatic ICHMTICI scoreFailed recanalizationPrimary outcomeFunctional outcomesPatientsVessel occlusionOutcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in Early and Late Time Windows
Elawady S, Cunningham C, Matsukawa H, Uchida K, Lin S, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Grossberg J, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Al Kasab S. Outcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in Early and Late Time Windows. Neurosurgery 2024, 95: 877-885. PMID: 39293795, DOI: 10.1227/neu.0000000000002992.Peer-Reviewed Original ResearchAlberta Stroke Program Early Computed Tomography ScoreLower Alberta Stroke Program Early Computed Tomography ScoreComputed tomography scoreLarge vessel occlusionMechanical thrombectomyRate of symptomatic ICHMedian admission National Institutes of Health Stroke Scale scoreAnterior circulation large vessel occlusionProportion of female patientsVessel occlusionPrevalence of atrial fibrillationIntracranial large vessel occlusionAdmission National Institutes of Health Stroke Scale scoreNational Institutes of Health Stroke Scale scoreMulticenter international registryOutcomes of mechanical thrombectomyRetrospective cohort studyWindow groupStroke Scale scoreSymptomatic ICHNo significant differenceFemale patientsPropensity matchingAtrial fibrillationInternational registry
2023
Risk factors and predictors of intracranial hemorrhage after mechanical thrombectomy in acute ischemic stroke: insights from the Stroke Thrombectomy and Aneurysm Registry (STAR)
Ironside N, Chen C, Chalhoub R, Wludyka P, Kellogg R, Al Kasab S, Ding D, Maier I, Rai A, Jabbour P, Kim J, Wolfe S, Starke R, Psychogios M, Shaban A, Arthur A, Yoshimura S, Grossberg J, Alawieh A, Fragata I, Polifka A, Mascitelli J, Osbun J, Matouk C, Levitt M, Dumont T, Cuellar-Saenz H, Williamson R, Romano D, Crosa R, Gory B, Mokin M, Moss M, Limaye K, Kan P, Spiotta A, Park M. Risk factors and predictors of intracranial hemorrhage after mechanical thrombectomy in acute ischemic stroke: insights from the Stroke Thrombectomy and Aneurysm Registry (STAR). Journal Of NeuroInterventional Surgery 2023, 15: e312-e322. PMID: 36725360, PMCID: PMC10962911, DOI: 10.1136/jnis-2022-019513.Peer-Reviewed Original ResearchConceptsEuropean Cooperative Acute Stroke StudyAcute ischemic stroke thrombectomyPredictors of intracranial hemorrhageAcute ischemic strokeIntracranial hemorrhageSymptomatic ICHRisk factorsStroke thrombectomyAneurysm RegistryIschemic strokeSymptomatic intracranial hemorrhageImprove patient outcomesPredicting intracranial hemorrhageReduced intracranial hemorrhageAcute Stroke StudyMechanical thrombectomy techniquesMultivariate regression modelInfarction 1Retrospective reviewIntraprocedural complicationsProcedural complicationsPatient outcomesStroke StudyStudy cohortSubgroup analysis
2016
Cortical superficial siderosis predicts early recurrent lobar hemorrhage
Roongpiboonsopit D, Charidimou A, William CM, Lauer A, Falcone GJ, Martinez-Ramirez S, Biffi A, Ayres A, Vashkevich A, Awosika OO, Rosand J, Gurol ME, Silverman SB, Greenberg SM, Viswanathan A. Cortical superficial siderosis predicts early recurrent lobar hemorrhage. Neurology 2016, 87: 1863-1870. PMID: 27694268, PMCID: PMC5100711, DOI: 10.1212/wnl.0000000000003281.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisConvexity subarachnoid hemorrhageCerebral amyloid angiopathyRecurrent ICHSuperficial siderosisAcute convexity subarachnoid hemorrhageDisseminated cortical superficial siderosisSingle-center cohort studyBaseline ICH volumeRecurrent lobar hemorrhageProportional hazards modelWhite matter hyperintensitiesIntracerebral hemorrhage recurrenceLobar hemorrhageLobar ICHSymptomatic ICHBoston criteriaConsecutive survivorsCohort studyAmyloid angiopathyHemorrhage recurrenceIndependent predictorsUnivariable analysisCerebral microbleedsIndex event
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