2023
Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans
Naps M, Leong S, Hartwell E, Rentsch C, Kranzler H. Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans. Alcohol Clinical And Experimental Research 2023, 47: 438-447. PMID: 36810985, DOI: 10.1111/acer.15011.Peer-Reviewed Original ResearchConceptsSerum bicarbonate concentrationAlcohol use disorderMetabolic acidosisMEq/LAlcohol consumptionTopiramate therapyAlcohol Use Disorders Identification Test-Consumption scoresVeterans Health Administration electronic health record dataBicarbonate concentrationPropensity score-matched control groupPropensity score-matched controlsMean daily dosageSignificant metabolic acidosisElectronic health record dataDiagnosis of AUDHealth record dataBaseline alcohol consumptionDifferences linear regression modelThree-level measureAcid-base balanceTopiramate dosageTopiramate prescriptionsMean followTopiramate treatmentDaily dosage
2017
The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing
Kothari D, Ketwaroo G, Freedman S, Sheth S. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas 2017, 46: 887-890. PMID: 28697128, DOI: 10.1097/mpa.0000000000000871.Peer-Reviewed Original ResearchConceptsRecurrent acute pancreatitisPeak bicarbonate concentrationHistory of APAcute pancreatitisRisk factorsPancreatic function testingChronic pancreatitisLocal complicationsFunction testingFemale sexBicarbonate concentrationRetrospective reviewUnivariate analysisFamily historyTobacco usePancreatitisPatientsMultivariate analysisAlcohol useComplicationsSignificant differencesSexFactorsHistoryComparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis
Kothari D, Ketwaroo G, Sawhney M, Freedman S, Sheth S. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis. Pancreas 2017, 46: 770-775. PMID: 28609365, DOI: 10.1097/mpa.0000000000000829.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCross-Over StudiesEndoscopes, GastrointestinalEndoscopy, GastrointestinalEndosonographyFeasibility StudiesFemaleHumansMaleMiddle AgedPancreatic Function TestsPancreatic JuicePancreatitis, ChronicPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSecretinTime FactorsWorkflowConceptsChronic pancreatitisPeak bicarbonate concentrationPancreatic function testsEndoscopic ultrasonographyFunction testsPoor concordanceProspective crossover studyPancreatic function testingFunctional testsBicarbonate concentrationPeak bicarbonateSecretin testingCrossover studyFunction testingTest concordanceDiscordant findingsFunctional assessmentPatientsImproved concordancePancreatitisSignificant correlationUltrasonographyConcordanceFeasible testCutoff
2006
Long‐term comparison of sevelamer hydrochloride to calcium‐containing phosphate binders
BREWSTER UC, CIAMPI MA, ABU‐ALFA A, REILLY RF. Long‐term comparison of sevelamer hydrochloride to calcium‐containing phosphate binders. Nephrology 2006, 11: 142-146. PMID: 16669977, DOI: 10.1111/j.1440-1797.2006.00544.x.Peer-Reviewed Original ResearchConceptsCalcium-containing bindersSerum phosphorus concentrationLower serum bicarbonate concentrationEnd-stage renal diseaseCalcium-phosphorus productSerum bicarbonate concentrationSevelamer hydrochloridePhosphate bindersCalcium-containing phosphate bindersElevated calcium-phosphorus productHigher serum phosphorus concentrationsMmol2/L2Retrospective chart reviewLong-term efficacyCa-P productLong-term comparative studiesBicarbonate concentrationESRD patientsChart reviewRenal diseaseCalcium loadPatientsLong-term comparisonTarget goalsEfficacy
1998
Acid-base Homeostasis in Children With Growth Hormone Deficiency
Glaser N, Shirali A, Styne D, Jones K. Acid-base Homeostasis in Children With Growth Hormone Deficiency. 1998, 102: 1407-1414. PMID: 9832577, DOI: 10.1542/peds.102.6.1407.Peer-Reviewed Original ResearchConceptsMean serum bicarbonate concentrationSerum bicarbonate concentrationGrowth hormone deficiencyStandard deviation scoreGH treatmentShort statureGrowth hormoneAcid-base homeostasisHormone deficiencyBicarbonate concentrationLower serum bicarbonate concentrationMild metabolic acidosisSerum electrolyte concentrationsNormal acid-base homeostasisCause of acidosisRenal functionUnclear etiologyMetabolic acidosisMedical recordsOverall prevalenceGrowth failureDeviation scoreStudy populationPatientsIntermediate probability
1993
Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule.
Wang T, Malnic G, Giebisch G, Chan Y. Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule. Journal Of Clinical Investigation 1993, 91: 2776-2784. PMID: 8390489, PMCID: PMC443344, DOI: 10.1172/jci116519.Peer-Reviewed Original ResearchConceptsLate distal tubuleBicarbonate absorptionDistal tubulesTubule segmentsBicarbonate transportH-ATPaseH-K-ATPase inhibitorsRate of bicarbonate absorptionEthyl-isopropylamilorideFluid absorptionNa(+)-H+ exchangeK(+)-H+ exchangeEarly distal tubuleBicarbonate transport mechanismDistal tubule segmentsRenal bicarbonate reabsorptionLow-K dietLuminal bicarbonate concentrationBicarbonate reabsorptionBicarbonate secretionBicarbonate concentrationH+ secretionMicroperfusion experimentsTubulesK diet
1986
Effect of hyperketonemia on renal ammonia excretion in man
Desir G, Bratusch-Marrain P, DeFronzo R. Effect of hyperketonemia on renal ammonia excretion in man. Metabolism 1986, 35: 736-743. PMID: 3736414, DOI: 10.1016/0026-0495(86)90241-6.Peer-Reviewed Original ResearchConceptsUrinary ammonia excretionVenous pHBlood pHBicarbonate concentrationEffects of hyperketonemiaBaseline bloodAbsence of changesContinuous infusionRenal ammonia excretionMetabolic acidosisBeta-OHBBody weightDay 4Mumol/ExcretionInfusionUrine samplesSimilar increaseUrineHuman subjectsAmmonia excretionNADH ratioSubjectsSodium lactateMinutes
1984
Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion.
Alpern RJ. Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion. Journal Of General Physiology 1984, 84: 753-770. PMID: 6096481, PMCID: PMC2228763, DOI: 10.1085/jgp.84.5.753.Peer-Reviewed Original Research
1983
Flow dependence of proximal tubular bicarbonate absorption
Alpern RJ, Cogan MG, Rector FC. Flow dependence of proximal tubular bicarbonate absorption. American Journal Of Physiology 1983, 245: f478-f484. PMID: 6414312, DOI: 10.1152/ajprenal.1983.245.4.f478.Peer-Reviewed Original ResearchConceptsLuminal bicarbonate concentrationBicarbonate absorptionFlow-dependent increaseFlow-dependent decreaseProximal convoluted tubulesBicarbonate concentrationFlow-induced increaseFlow-dependent changesConvoluted tubulesX minPmol xStimulationProton secretionTubulesPerfusion rateMaximal rateObserved stimulationMinEffects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.
Alpern RJ, Cogan MG, Rector FC. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. Journal Of Clinical Investigation 1983, 71: 736-746. PMID: 6826733, PMCID: PMC436924, DOI: 10.1172/jci110821.Peer-Reviewed Original ResearchConceptsNet bicarbonate absorptionExtracellular fluid volumeVolume-expanded ratsLuminal bicarbonate concentrationPlasma bicarbonate concentrationBicarbonate absorptionVolume statusFluid volumeBicarbonate concentrationProton secretionExtracellular fluid volume statusBicarbonate permeabilityFluid volume statusPeritubular bicarbonate concentrationsProximal acidificationHydropenic ratsRatsAcidotic ratsSecretionAbove inhibitionLuminal compositionAlkalosisVolume expansionTubulesMM bicarbonate
1982
Effect of luminal bicarbonate concentration on proximal acidification in the rat
Alpern RJ, Cogan MG, Rector FC. Effect of luminal bicarbonate concentration on proximal acidification in the rat. American Journal Of Physiology 1982, 243: f53-f59. PMID: 7091367, DOI: 10.1152/ajprenal.1982.243.1.f53.Peer-Reviewed Original ResearchConceptsLuminal bicarbonate concentrationBicarbonate absorptionBicarbonate concentrationNet bicarbonate absorptionProximal convoluted tubulesProximal tubular acidificationProton secretionBicarbonate leakProximal acidificationTubular acidificationConvoluted tubulesBicarbonate permeabilitySecretionRats
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