2025
Mechanism of Impaired Potassium Transport in Pseudohypoaldosteronism
Wan L, Lessa L, Shen H, Malnic G, Giebisch G, Wang T. Mechanism of Impaired Potassium Transport in Pseudohypoaldosteronism. Physiology 2025, 40: 0956. DOI: 10.1152/physiol.2025.40.s1.0956.Peer-Reviewed Original ResearchMaxi-K channelsK+ secretionMaxi-KPseudohypoaldosteronism type IILate distal tubuleDistal tubulesHK intakeInhibitor iberiotoxinNaCl cotransporterDistal nephronNaCl reabsorptionConductance Ca2+-activated K+Thiazide-sensitive NaCl cotransporterCa2+-activated K+Renal outer medullary potassiumCortical distal tubulesRenal NaCl reabsorptionIncreased K+ secretionReduced NaCl reabsorptionWNK4 mutationsDouble-barreled microelectrodesChannel-mediated mechanismsNCC expression-activated K+WT mice
2006
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet
Bailey M, Cantone A, Yan Q, MacGregor G, Leng Q, Amorim J, Wang T, Hebert S, Giebisch G, Malnic G. Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney International 2006, 70: 51-59. PMID: 16710355, DOI: 10.1038/sj.ki.5000388.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBartter SyndromeBiological TransportDietDisease Models, AnimalHypokalemiaKidney Tubules, DistalLarge-Conductance Calcium-Activated Potassium ChannelsLoop of HenleMiceMice, Mutant StrainsPeptidesPotassiumPotassium Channels, Inwardly RectifyingPotassium, DietaryConceptsCortical collecting ductLate distal tubuleType II Bartter syndromeRenal potassium wastingMaxi-K channelsPotassium secretionDistal tubulesBartter's syndromePotassium wastingPotassium excretionIberiotoxin (IBTX)-sensitiveRenal potassium lossSalt-wasting disorderUrinary potassium excretionWild-type miceRenal potassium excretionFree-flow micropunctureDistal convoluted tubuleIncreased renal potassium excretionHigh-K dietLoop of HenleROMK-deficientPersistent hypokalemiaROMK channelsMaxi-K
1999
Immunolocalization of the electrogenic Na+- HCO 3 − cotransporter in mammalian and amphibian kidney
Schmitt B, Biemesderfer D, Romero M, Boulpaep E, Boron W. Immunolocalization of the electrogenic Na+- HCO 3 − cotransporter in mammalian and amphibian kidney. American Journal Of Physiology 1999, 276: f27-f38. PMID: 9887077, DOI: 10.1152/ajprenal.1999.276.1.f27.Peer-Reviewed Original ResearchConceptsRat kidney NBCProximal tubulesDistal tubulesIndirect immunofluorescence microscopyEarly distal tubuleLate distal tubuleControl fusion proteinHCO-3 reabsorptionHCO-3 cotransporterRenal proximal tubulesBasolateral labelingImmunofluorescence microscopyRenal microsomesGuinea pigsRat kidneyHEK-293 cellsKidneyPreabsorption experimentsBasolateral stainingRabbit kidneyControl oocytesFusion proteinRatsProtein levelsNBC protein
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsEffects of Ang IIAng IILate distal tubuleDistal tubulesDecreased JvAngiotensin IIHigher dose of Ang IILow doses of angiotensin IILuminal application of amilorideAmiloride-sensitive Na+ transportDose of Ang IIRat kidneyHCO3- transportAddition of ANG IIDoses of angiotensin IIEffects of angiotensin IIApplication of amilorideStimulate Na+/H+ exchangeProximal tubules of rat kidneyDistal convoluted tubuleLuminal administrationNa+ channelsNa+/H+ exchangeDistal nephronIntravenous infusion
1993
Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule.
Wang T, Malnic G, Giebisch G, Chan Y. Renal bicarbonate reabsorption in the rat. IV. Bicarbonate transport mechanisms in the early and late distal tubule. Journal Of Clinical Investigation 1993, 91: 2776-2784. PMID: 8390489, PMCID: PMC443344, DOI: 10.1172/jci116519.Peer-Reviewed Original ResearchConceptsLate distal tubuleBicarbonate absorptionDistal tubulesTubule segmentsBicarbonate transportH-ATPaseH-K-ATPase inhibitorsRate of bicarbonate absorptionEthyl-isopropylamilorideFluid absorptionNa(+)-H+ exchangeK(+)-H+ exchangeEarly distal tubuleBicarbonate transport mechanismDistal tubule segmentsRenal bicarbonate reabsorptionLow-K dietLuminal bicarbonate concentrationBicarbonate reabsorptionBicarbonate secretionBicarbonate concentrationH+ secretionMicroperfusion experimentsTubulesK diet
1989
Neural control of distal tubular bicarbonate and fluid transport
Wang T, Chan Y. Neural control of distal tubular bicarbonate and fluid transport. American Journal Of Physiology 1989, 257: f72-f76. PMID: 2750926, DOI: 10.1152/ajprenal.1989.257.1.f72.Peer-Reviewed Original ResearchConceptsDistal convoluted tubuleConvoluted tubulesDistal tubulesRate of bicarbonate absorptionRenal nerve activityLate distal tubuleEarly distal tubuleTubular reabsorption of bicarbonateEffects of denervationReabsorption of bicarbonateRate of fluid absorptionNerve activityBicarbonate absorptionSham denervationElectrolyte excretionFluid reabsorptionDenervated kidneysReabsorb bicarbonateJHCO3DenervationFluid absorptionNeural regulationVolume markerTubulesMicroperfusion method
1984
Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium
Stanton B, Biemesderfer D, Stetson D, Kashgarian M, Giebisch G. Cellular ultrastructure of Amphiuma distal nephron: effects of exposure to potassium. American Journal Of Physiology 1984, 247: c204-c216. PMID: 6476108, DOI: 10.1152/ajpcell.1984.247.3.c204.Peer-Reviewed Original ResearchConceptsEarly distal tubuleDistal tubulesDistal nephronPotassium adaptationRenal distal nephronLarge cell typeLate distal tubuleCortical collecting tubuleSmooth muscle cellsLate distalAfferent arteriolesEffects of exposureJuxtaglomerular apparatusMammalian cortical collecting tubuleCollecting tubuleEarly distalHenle's loopBasolateral membrane surface densityMuscle cellsPrincipal cellsCellular mechanismsNephronStereological techniquesTubulesUseful preparation
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9Rats
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