1993
Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.
Alvaro D, Cho W, Mennone A, Boyer J. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. Journal Of Clinical Investigation 1993, 92: 1314-1325. PMID: 8397224, PMCID: PMC288273, DOI: 10.1172/jci116705.Peer-Reviewed Original ResearchConceptsBile duct epithelial cellsDuct epithelial cellsCl-/HCO3Cell depolarizationEpithelial cellsEffect of secretinCl- channel blockerEffects of secretionsCl removalCl- channel activationRat bile duct epithelial cellsKRB mediumMaximal rateRegulation of intracellularBicarbonate secretionNormal rat liverIntracellular pH regulationMM DIDSHCO3- excretionAcid loadBDE cellsSecretinMicrofluorimetric methodRat liverHCO3- influxThe function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury
Borutaité V, Mildažiene V, Katiliūté Z, Kholodenko B, Toleikis A. The function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury. Biochimica Et Biophysica Acta 1993, 1142: 175-180. PMID: 8457582, DOI: 10.1016/0005-2728(93)90099-2.Peer-Reviewed Original ResearchConceptsATP/ADP translocatorHeart ischemic injuryNormal mitochondriaInhibitor titration studiesRate of succinateIschemic injuryMin ischemiaMitochondrial respiratory rateRespiratory rateOxidative phosphorylationTranslocatorMitochondrial respirationMalate oxidationMitochondriaState 3Heart mitochondriaTotal ischemiaControl coefficientsIschemiaState 4RegulationIschemic mitochondriaInjuryPhosphorylationMaximal rate
1991
Regulation of the heart mitochondrial respiration rate. Comparison of oxidation of succinate and NAD-dependent substrates.
Kholodenko B, Millazhane V, Borutaĭte V, Ivanovene L, Iuodkaĭte R, Katiliute Z, Toleĭkis A. Regulation of the heart mitochondrial respiration rate. Comparison of oxidation of succinate and NAD-dependent substrates. Биохимия 1991, 56: 1420-8. PMID: 1782265.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocatorNAD-dependent substratesSame relative rateInner mitochondrial membraneProton leakageMitochondrial respiration rateState 4Mitochondrial processesExtramitochondrial adenine nucleotidesMitochondrial membraneState 3Nucleotide translocatorRegulation of respirationRate of respirationSuccinate dehydrogenaseSuccinate oxidationHeart mitochondriaMembrane potentialRespirationRelative ratesRespiration rateMaximal rateRegulationControl of respirationControl coefficients
1988
The influence of variation and of developmental constraints on the rate of multivariate phenotypic evolution
Wagner G. The influence of variation and of developmental constraints on the rate of multivariate phenotypic evolution. Journal Of Evolutionary Biology 1988, 1: 45-66. DOI: 10.1046/j.1420-9101.1988.1010045.x.Peer-Reviewed Original ResearchRate of evolutionMultivariate phenotypic evolutionPhenotypic evolutionAdaptive landscapePhenotypic variationDevelopmental constraintsAdaptive phenotypic evolutionHeritable phenotypic variationPhenotypic varianceInterdependent characterNumber of charactersPossible roleLandscapeEvolutionOrganismic systemsMaximal rateVariationFunctionFitness functionCharacter
1983
Flow dependence of proximal tubular bicarbonate absorption
Alpern RJ, Cogan MG, Rector FC. Flow dependence of proximal tubular bicarbonate absorption. American Journal Of Physiology 1983, 245: f478-f484. PMID: 6414312, DOI: 10.1152/ajprenal.1983.245.4.f478.Peer-Reviewed Original ResearchConceptsLuminal bicarbonate concentrationBicarbonate absorptionFlow-dependent increaseFlow-dependent decreaseProximal convoluted tubulesBicarbonate concentrationFlow-induced increaseFlow-dependent changesConvoluted tubulesX minPmol xStimulationProton secretionTubulesPerfusion rateMaximal rateObserved stimulationMinIntracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange.
Boron W, Boulpaep E. Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange. Journal Of General Physiology 1983, 81: 29-52. PMID: 6833996, PMCID: PMC2215563, DOI: 10.1085/jgp.81.1.29.Peer-Reviewed Original ResearchConceptsProximal tubulesProximal tubule cellsRenal proximal tubulesTiger salamander Ambystoma tigrinumPH-sensitive microelectrodesFree RingerMaximal effectTubule cellsTransient riseDiuretic amilorideBasolateral sideBasolateral solutionExponential time courseSalamander Ambystoma tigrinumTime courseCl removalMaximal rateBasolateral membraneNormal rateTubulesAmbystoma tigrinumPH regulationCellsActive transportRecovery
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