Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Imai T, Jin X, Locascio J, Boisserand L, Herman A, Chauhan A, Lamb J, Nagarkatti K, Diniz M, Kumskova M, Dhanesha N, Kamat P, Khan M, Dhandapani K, Patel R, Sutariya B, Shi Y, van Leyen K, Kimberly W, Hess D, Aronowski J, Leira E, Koehler R, Chauhan A, Sansing L, Lyden P, Ayata C. Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial. Circulation Research 2024, 135: 575-592. PMID: 39034919, PMCID: PMC11428171, DOI: 10.1161/circresaha.123.324139.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionFilament middle cerebral artery occlusionHigh-fat dietProcedural variablesHigh-fatOlder ageStroke outcomeBlood flow monitoringCerebral blood flow monitoringPredictors of outcomeBody weightProspective designInfluence stroke outcomeAssociated with smaller infarctsCerebral artery occlusionExperimental focal cerebral ischemiaFocal cerebral ischemiaLonger anesthesia durationExperimental stroke modelsBlood flow dropAcute stroke interventionExperimental stroke outcomesMulticenter prospective designProcedural predictorsPreclinical studies
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