2023
Trained immunity induced by high‐salt diet impedes stroke recovery
Lin T, Jiang D, Chen W, Lin J, Zhang X, Chen C, Hsu C, Lai L, Chen P, Yang K, Sansing L, Chang C. Trained immunity induced by high‐salt diet impedes stroke recovery. EMBO Reports 2023, 24: e57164. PMID: 37965920, PMCID: PMC10702837, DOI: 10.15252/embr.202357164.Peer-Reviewed Original ResearchConceptsInnate immune memoryMonocyte-derived macrophagesStroke recoveryInflammatory responseBone marrowImmune memoryHigh-salt dietCause of morbidityInitial inflammatory responsePotential therapeutic targetLoss of Nr4a1Stroke outcomeStroke brainIntracerebral hemorrhageBrain recoverySterile inflammationHealthy miceTissue injurySevere formTherapeutic targetAlternative activationImmune primingReparative functionsProgenitor cellsNR4A family
2016
Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis
Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis. Journal Of Clinical Investigation 2016, 126: 4331-4345. PMID: 27721238, PMCID: PMC5096920, DOI: 10.1172/jci85740.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stromal cellsDendritic cellsSkin fibrosisDermal white adipose tissueFibrotic skinAdipose tissueStromal cellsMesenchymal stromal cell therapyScleroderma skin fibrosisStromal cell therapyWhite adipose tissueAdipose-derived stromal cellsMesenchymal stromal cellsΒ expressionMurine modelEffective treatmentFibrosisΒ1-integrin pathwayReparative functionsCell therapySclerodermaSkin functionIntegrin pathwaySurvivalAtrophy
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