2024
Molecular mechanisms of Coxiella burnetii formalin-fixed cellular vaccine reactogenicity
Fratzke A, Szule J, Butler S, Schaik E, Samuel J. Molecular mechanisms of Coxiella burnetii formalin-fixed cellular vaccine reactogenicity. Infection And Immunity 2024, 92: e00335-24. PMID: 39356158, PMCID: PMC11556133, DOI: 10.1128/iai.00335-24.Peer-Reviewed Original ResearchCD4+ T cellsSmall cell variantWhole cell vaccineWeeks post-injectionSite of vaccinationT cellsCell variantPost-injectionAdoptive transfer experimentsLocal reactionsDelayed-type hypersensitivitySite of injectionCD8+Antigen persistenceCell vaccineQ-VaxCD4Mouse modelRod-shaped bacteriaHistological changesReactogenicityGuinea pigsVaccineCytokinesWeeks
2013
Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
Tan W, Low W, Ng C, Tan W, Tong S, Ho C, Khoo E, Lee G, Lee B, Lee V, Tan H. Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study. BJU International 2013, 111: 1130-1140. PMID: 23651425, DOI: 10.1111/bju.12037.Peer-Reviewed Original ResearchConceptsProstate-specific antigenTestosterone undecanoateTestosterone deficiencyTreatment armsAdverse eventsSex hormone-binding globulinIntramuscular testosterone undecanoateCommon adverse eventsIncreased serum testosteroneHormone-binding globulinLiver function testsCessation of treatmentFasting blood glucosePhysical examination resultsRandomised controlled studySite of injectionTU injectionsPlacebo armSerum TTSerum testosteroneSpecific antigenAdverse reactionsLipid profileFunction testsControlled studies
2010
Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
Sasaki M, Lankford KL, Brown RJ, Ruddle NH, Kocsis JD. Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor. Glia 2010, 58: 1523-1531. PMID: 20645414, DOI: 10.1002/glia.21026.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodiesBlood-Brain BarrierCD3 ComplexDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFreund's AdjuvantInjections, SpinalLipidsMicroscopy, Electron, TransmissionMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsRats, Inbred LewSpinal CordTime FactorsVascular Endothelial Growth Factor AConceptsMyelin oligodendrocyte glycoproteinVascular endothelial growth factorExperimental autoimmune encephalomyelitisIncomplete Freund's adjuvantBlood-brain barrierInflammatory demyelinating lesionsLewis ratsEndothelial growth factorDemyelinating lesionsEAE modelAutoimmune encephalomyelitisFreund's adjuvantIntraspinal injectionOligodendrocyte glycoproteinRecombinant rat myelin oligodendrocyte glycoproteinCentral nervous system locationsGrowth factorSensitized T cellsFocal experimental autoimmune encephalomyelitisRat myelin oligodendrocyte glycoproteinSite of injectionMyelin-forming cellsMOG immunizationExtensive demyelinationLymphocyte infiltration
2004
Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes. Circulation 2004, 111: 11-20. PMID: 15611367, DOI: 10.1161/01.cir.0000151313.18547.a2.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdrenergic beta-AgonistsAnimalsCell DifferentiationCell FusionCells, CulturedDefective VirusesElectrophysiologyFemaleGenes, ReporterGenetic VectorsGiant CellsGreen Fluorescent ProteinsGuinea PigsHeartHeart Conduction SystemHeart VentriclesHIV-1HumansIsoproterenolLidocaineMiceMyocardial ContractionMyocytes, CardiacOrgan Culture TechniquesPericardiumPluripotent Stem CellsPyrimidinesRatsTransduction, GeneticConceptsVentricular cardiomyocytesCardiac impulse generationBeta-adrenergic agonist isoproterenolGuinea pig heartsSite of injectionStem cellsHuman embryonic stem cellsCell-based therapiesContractile activityAgonist isoproterenolPharmacological agentsVentricular myocardiumLeft ventricleEx vivoDonor cardiomyocytesPig heartsHuman cardiomyocytesRecombinant lentivirusMembrane depolarizationCardiomyocytesFunctional syncytiumImpulse generationEmbryonic stem cellsMyocardiumEpicardial surfaceEfficacy and toxicity of pentavalent antimonials (Glucantime and Pentostam) in an American cutaneous leishmaniasis animal model: luminometry application.
Henao HH, Osorio Y, Saravia NG, Gómez A, Travi B. Efficacy and toxicity of pentavalent antimonials (Glucantime and Pentostam) in an American cutaneous leishmaniasis animal model: luminometry application. Biomédica 2004, 24: 393-402. PMID: 15678803, DOI: 10.7705/biomedica.v24i4.1289.Peer-Reviewed Original ResearchConceptsAnti-Leishmania treatmentNormal serum levelsFirst-line drugsRight hind footSite of injectionParasitological efficacySerum levelsClinical efficacyLesion reductionCure rateLine drugsPentavalent antimonialsSimilar efficacyHepatic alterationsAlanine aminotransferaseLocal toxicityClinical observationsMicroscopic signsTreatment efficacyAnimal modelsHigh dosesLeishmania panamensisAspartate aminotransferaseParasite burdenGlucantime
1999
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors
D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunology, Immunotherapy 1999, 47: 265-271. PMID: 10022470, PMCID: PMC11037327, DOI: 10.1007/s002620050530.Peer-Reviewed Original ResearchConceptsGene therapy strategiesAmplicon vectorsInterleukin-2Enzyme-linked immunosorbent assaySite of injectionIn vivo gene therapy strategiesEfficient gene-transfer vehiclesInterleukin-2 gene therapyTransfer of cytokine genesGene transferEfficiency of in vivo gene transferCytokine gene transferGene-transfer approachHSV amplicon vectorsNon-injected tumorsProduction of interleukin-2Efficient gene transferGene-transfer vehiclesGrowth of tumorsGene-transfer methodsIn vivo injectionInjected tumorsEstablished tumorsIntratumoral administrationAntitumor efficacy
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