2023
Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy
Rupert C, López J, Cortez-Toledo E, De la Cruz Cabrera O, Chesler N, Simpson P, Campbell S, Baker A. Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy. AJP Heart And Circulatory Physiology 2023, 324: h293-h304. PMID: 36637971, PMCID: PMC9886349, DOI: 10.1152/ajpheart.00279.2022.Peer-Reviewed Original ResearchConceptsHuman heart failureHeart failureAR stimulationChronic stimulationLength-dependent activationVehicle treatmentHeart tissueAdrenergic receptorsHuman EHTsAnimal heart failure modelNovel heart failure therapiesHeart failure therapyHeart failure modelMultiple preclinical modelsFailure therapyAgonist treatmentSeparate control experimentsPreclinical modelsDrug washoutTherapeutic effectTranslational significanceHuman myocardiumBaseline testingRNA-seq analysisPig myocardiumImproving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches
Casper S, Kayani T, Galerneau F, Evans L, Pal L. Improving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches. International Journal Of Gynecology & Obstetrics 2023, 161: 1033-1039. PMID: 36527258, DOI: 10.1002/ijgo.14631.Peer-Reviewed Original ResearchConceptsPostpartum hemorrhagePPH managementEmergency medicine residentsManagement of PPHMedicine residentsPost-intervention assessmentT-testStudent's t-testClinical skills scoresBaseline testingImprovement of knowledgeParticipants' knowledgeDidactic lecturesHemorrhageEM residentsSimulation-based trainingDidactic sessionsForm of interventionEffects of covariatesAddition of simulationStructured curriculumNovel curriculumParticipants
2019
Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study
Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Epilepsia 2019, 61: 19-28. PMID: 31646628, PMCID: PMC7424790, DOI: 10.1111/epi.16356.Peer-Reviewed Original ResearchConceptsEpileptiform dischargesGeneralized epileptiform dischargesEEG amplitudeClinical seizuresElectroencephalographic featuresGeneralized epilepsyLarger sample sizeDriving impairmentClinical accompanimentBaseline testingPilot studyMotor vehicle safetyLonger durationSimultaneous EEGSeizuresVisual stimuliEEGSubjectsStimuliRiskSafetyDurationSample sizeResponseEpilepsy
2000
Midazolam: Effects on Amnesia and Anxiety in Children
Kain Z, Hofstadter M, Mayes L, Krivutza D, Alexander G, Wang S, Reznick J. Midazolam: Effects on Amnesia and Anxiety in Children. Anesthesiology 2000, 93: 676. PMID: 10969300, DOI: 10.1097/00000542-200009000-00016.Peer-Reviewed Original ResearchConceptsOral midazolamMidazolam administrationAnterograde amnesiaGood anterograde amnesiaSignificant anterograde amnesiaInduction of anesthesiaSignificant anxiolytic effectMidazolam groupGeneral anesthesiaSignificant group differencesAnxiolytic effectsBusy operating roomSurgical proceduresPostintervention testingDrug AdministrationControl groupMidazolamBaseline testingAnxiety measurement toolAnxiety of childrenOperating roomAdministrationGroup differencesPicture cardsAnesthesia
1993
A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients
Silberstein C, O'Dowd M, Chartock P, Schoenbaum E, Friedland G, Hartel D, McKegney F. A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients. General Hospital Psychiatry 1993, 15: 351-359. PMID: 8112557, DOI: 10.1016/0163-8343(93)90001-5.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionCentral nervous system impairmentHIV antibody testingImmunodeficiency virus infectionMethadone-maintained patientsSymptoms/signsNervous system impairmentMethadone maintenance clinicsNeuropsychological Screening BatteryTrail Making B testSubtle cognitive deficitsHIV infectionAntibody testingPhysical examMaintenance clinicsVirus infectionBaseline testingNeuropsychological functionCognitive deficitsNP assessmentFinger tappingSystem impairmentScreening batteryLongitudinal studyPatients
1990
A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients
McKegney F, O'Dowd M, Feiner C, Selwyn P, Drucker E, Friedland G. A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients. AIDS 1990, 4: 565-570. PMID: 2386618, DOI: 10.1097/00002030-199006000-00011.Peer-Reviewed Original ResearchConceptsPsychological Screening TestMethadone clinic patientsMethadone-maintained populationsEvidence of HIVMethadone-maintained patientsDigit spanProspective longitudinal studyPsychosocial functioningNeuropsychologic functionRace/ethnicityPsychosocial assessmentCognitive impairmentHIV antibodiesHIV infectionLongitudinal studyUnivariate analysisMean intervalProspective comparisonSerological testingSerological statusPhysical symptomsDrug useBaseline testingScreening testSeropositives
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