2025
Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9.
Jacobson O, Zhang H, Olkowski C, Ghaemi B, Basuli F, Shi J, Bell M, Parween F, Ganesan S, Esparza T, Escorcia F, Choyke P, Farber J. Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9. Journal Of Nuclear Medicine 2025, 66: 1372-1377. PMID: 40813232, PMCID: PMC12410298, DOI: 10.2967/jnumed.125.269795.Peer-Reviewed Original ResearchConceptsC-X-C motif chemokine ligand 9T cell activationT cell-engaging therapiesHumanized mouse modelT cellsTumor microenvironmentIFN-gXenograft modelGroup 1 innate lymphoid cellsEfficacy of cancer immunotherapyEngaging therapiesMethods:</b>Biomarkers of immune activationTumor-to-background ratioResults:</b>PET imagingResponse to immunotherapyTumor-to-backgroundImmune-mediated diseasesMonitoring of immune responsesSubcutaneous xenograft modelChemokine ligand 9Monitoring T-cell activationNoninvasive visualizationNoninvasive monitoring
2013
Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer
Isobe T, Onn A, Morgensztern D, Jacoby JJ, Wu W, Shintani T, Itasaka S, Shibuya K, Koo PJ, O'Reilly MS, Herbst RS. Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer. Journal Of Thoracic Oncology 2013, 8: 140-146. PMID: 23328546, DOI: 10.1097/jto.0b013e3182725ff9.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerHuman small cell lung cancerLymph nodesLung cancerMurine modelOrthotopic nude mouse modelHuman SCLC tumorsAxillary lymph nodesOrthotopic murine modelNovel therapeutic strategiesSubcutaneous xenograft modelTumor growth patternNude mouse modelEffective murine modelLeft lungRight lungTumor sizeSolitary massSCLC tumorsOrthotopic modelMouse modelNew therapiesTherapeutic strategiesXenograft modelNude mice
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply