Research & Publications
Dr. Hyder is Professor of Radiology & Biomedical Imaging and Professor of Biomedical Engineering, where he is a founding faculty member. He is Head of MRS Group of the MRRC and Director of QNMR Research Program. He studied physical chemistry at Wabash College (BA 1990) and biophysical chemistry at Yale University (PhD 1995).
Dr. Hyder studies brain energy metabolism. His lab develops magnetic resonance (MR) based imaging methods to study brain physiology and chemistry, revealing how neuronal-glial cells fuel their function and (re)growth. He posits that mapping metabolic dysfunction (e.g., energetics for cellular function vs. cellular proliferation) can indicate early biomarkers of brain disorders and diseases. To map brain’s physiology and chemistry with MR-based imaging and spectroscopic advances and targeted delivery and monitoring of treatments, his laboratory conducts multidisciplinary functional and molecular imaging of neurodegeneration and neuro-oncology, requiring expertise in physics to chemistry to engineering to cancer biology to neuroscience. His contributions include development of high-resolution fMRI in preclinical models, calibrated fMRI for quantitative imaging of neuronal activity, and molecular imaging methods for pH and temperature mapping and other physiological parameters that are relevant in cancer diagnosis and treatment.
Dr. Hyder has written and edited books on functional brain imaging and holds several patents on molecular imaging of cancer. His research work has produced over 240 papers with as many invited presentations, amassing over 20k citations. He has had continuous NIH support for 25 years, spanning across interests from 7 different NIH institutes. He has renewed grants from different funding agencies and has received several early career awards from. He sits on editorial boards of several scientific journals, and he reviews for many scientific journals spanning several disciplines. He serves on advisory panels of several funding agencies.
Dr. Hyder holds many honors, including the Melvin H. Knisely Award from the International Society on Oxygen Transport to Tissue, the Niels Lassen Award from the International Society for Cerebral Blood Flow and Metabolism, and the Lundbeck Foundation Visiting Professorship at the University of Copenhagen. He has fellowships in American Institute for Medical and Biological Engineering, Academy of Radiology & Biomedical Imaging Research, and Sigma Xi the Scientific Research Honor Society. Recently, he was appointed Head of Trumbull College at Yale University and received a General Assembly Official Citation from the State of Connecticut.
Education & Training
- PhDYale University, Chemistry (1995)
- BAWabash College, Chemistry (1990)
- Associate Research ScientistYale University
- Post-Doctoral Associate (with Douglas L. Rothman)Yale University
- Research Fellow (with Tuan Vo-Dinh)Oak Ridge National Laboratory, Oak Ridge, TN
- Research Fellow (with Robert G. Bryant)University of Rochester
- Imaging and NMR Studies of Brain MetabolismMiami, Florida, United States 2012Professor Hyder collaborates with Professor Jorge Riera of Florida International University, Miami, Florida. These collaborations focus on imaging and NMR studies of brain metabolism in health and disease.
- High Resolution PET Imaging of Human BrainCopenhagen, Capital Region, Denmark 2012Professor Hyder collaborates with Professor Albert Gjedde of University of Copenhagen, Copenhagen, Denmark. These collaborations focus on imaging of brain metabolism in health humans with PET technology.
- High resolution of PET Imaging of Anesthesia in Human BrainIrvine, California, United States 2012Professor Hyder collaborates with Professor Michael Alkire of University of California, Irvine, California. These collaborations focus on imaging of brain metabolism under anesthesia in health humans with PET technology.
- Brain Regional Temperature ChangesWuppertal, North Rhine-Westphalia, Germany 2008Professor Hyder collaborates with Hubert Trubel of Bayer Health Care AG, Wuppertal, Germany. The collaborations focus on temperature changes and oxygen efflux in the brain.
- fMRI Studies During non-Chemically Based HypotensionBudapest, Budapest, Hungary 2008Professor Hyder participates in collaborative research with Professor Andras Eke of the Institute of Human Physiology and Clinical Experimental Research at Semmelweis University in Budapest, Hungary. Research focuses on fMRI studies.
- Chair, Education Committee, International Society for Cerebral Blood Flow and Metabolism(2007-2009)Chair, Education Committee, International Society for Cerebral Blood Flow and Metabolism
- Odor Stimuli in Olfactory BulbWuhan, Hubei, China 2007Professor Hyder participates in collaborative research with Professor Fuqiang Xu of the Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China. These collaborations focus on the assessment and discrimination of odor stimuli by dynamic fMRI.
- Executive Committee, International Society on Oxygen Transport to Tissue(2005-2010)Executive Committee, International Society on Oxygen Transport to Tissue
- Board of Directors, International Society for Cerebral Blood Flow and Metabolism(2005-2009)Board of Directors, International Society for Cerebral Blood Flow and Metabolism
Honors & Recognition
|General Assembly Official Citation||State of Connecticut||2023|
|Adjunct Fellow||John B. Pierce Laboratory||2021|
|Fellow||American Institute for Medical & Biological Engineering||2019|
|Distinguished Investigator Award||Academy of Radiology Research||2016|
|Lundbeck Foundation Visiting Professorship||University of Copenhagen||2014|
|Pilot Award||Yale-UCL Medical Technologies Collaborative: Imaging & Sensing||2013|
|Pilot Award||Juvenile Diabetes Research Foundation||2008|
|Niels Lassen Award||International Society for Cerebral Blood Flow and Metabolism||2003|
|21st Century Science Initiative Grant||Bridging Brain, Mind & Behavior, James S. McDonnell Foundation||2001|
|Melvin H. Knisely Award||International Society on Oxygen Transport to Tissue||2001|
|DBI Award||National Science Foundation||1998|
|FIRST Award||National Institutes of Health||1998|
|Young Scientist Award||International Society for Cerebral Blood Flow and Metabolism||1995|
|Promotion of Research in Science||Sigma Xi||1990|
|Outstanding Senior in Chemistry||Phi Lambda Upsilon||1990|
|Outstanding Senior in Chemistry||The American Institute of Chemists Foundation||1990|
|Lloyd and Howell Award in Chemistry||Wabash College, Crawforsdville, IN||1988|