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Research Programs

The Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), which is being supported by NINDS funding, brings together a multi-disciplinary group of neuroscientists at Yale who utilize novel magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for their research.
This Bioengineering Research Partnership (BRP), funded by NIH-NIBIB is pursuing a program of research on neocortical epilepsy and the improvement of treatment through MR imaging, using surgical resection and/or responsive neurostimulation.
Accurate, comprehensive quantification of regional left ventricular (LV) deformation is crucial for detection, risk stratification, and management of patients with ischemic heart disease. In this BRP, supported by NIH, four partners from two academic institutions and industry will work together to develop and validate an integrated imaging/image analysis system that will accurately, robustly, and reproducibly quantify regional LV strain and strain rate from four-dimensional (3 spatial dimensions and time) echocardiographic (4DE) image sequences.
This Bioengineering Research Partnership (BRP) led by Dr. Constable, is aimed at developing fast MRI acquisition times. The work focuses on a novel approach to accelerated imaging that re-envisions the role of gradient encoding when using parallel receiver coil arrays to encode some of the spatial information. The approach introduces nonlinear gradient encoding that can achieve acceleration factors of two or more over current state-of-the-art methods.

The PET Center MHPRD program has been funded by the NIMH to research and develop a translational toolbox of radioligands to probe high priority molecular targets implicated in mental illness (7U01MH107803).