Dennis G Moledina, MD, PhD, FASN
Associate Professor of Medicine (Nephrology)Cards
About
Titles
Associate Professor of Medicine (Nephrology)
Director, Kidney BioBank, Internal Medicine
Biography
Dr. Dennis Moledina, MD PhD FASN is physician-scientist with board-certification in Internal Medicine with sub-specialization in Nephrology. He is an associate professor in the department of internal medicine (section of nephrology) at the Yale School of Medicine. He provides attending physician services at the Yale-New Haven Hospital in New Haven, CT in both nephrology and internal medicine. He completed clinical and post-doctoral fellowships in nephrology at Yale and earned his PhD in investigative medicine from the Yale Graduate School of Arts and Sciences. He has independent research funding from the NIH to develop diagnostic testing and tools for various subtypes of acute kidney injury. He is particularly interested in improving non-invasive diagnosis of acute interstitial nephritis, which is one of the few causes of acute kidney injury with diagnosis-specific management. He is a coinvestigator in NIH-funded multicenter consortia including Kidney Precision Medicine Program (KPMP) and Care of outpatients with acute kidney injury (COPE-AKI). He directs the Yale Kidney BioBank which is a biorepository that has collected samples from over 1200 participants with kidney biopsy confirmed diagnoses.
Appointments
Nephrology
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale Graduate School of Arts and Sciences, Investigative Medicine (2018)
- Postdoctoral Fellow
- Yale School of Medicine (2018)
- Clinical Fellow
- Yale School of Medicine (2015)
- Resident Physician
- NYU Grossman Long Island School of Medicine (2013)
- MD
- M.P. Shah Medical College (2009)
Research
Overview
Dr. Moledina is a board-certified nephrologist and a clinical researcher focused on improving understanding of human acute kidney injury (AKI) through biomarkers. He obtained training in clinical investigation through a post-doctoral fellowship in Nephrology research as well as a PhD in Investigative Medicine at Yale. His research experience includes leading the enrollment of a cohort of over 850 participants who underwent a kidney biopsy at Yale with simultaneous collection of biosamples with histologically-confirmed diagnosis. In this cohort, he identified diagnostic and prognostic biomarkers of AIN. He also evaluated participant perspectives towards donating tissue to research and factors for safe procurement of such tissue. He is a co-investigator at the Yale recruitment site of the NIDDK-sponsored Kidney Precision Medicine Program that obtains kidney tissue for research from participants with acute kidney injury. In this consortium, he serves as the co-chair of the “Laboratory sub-committee,” led the creation of the “biospecimen collection manual of operations,” and participated in the design of the overall protocol. Additionally, he is a co-investigator in NIH-funded cohorts studying AKI including the Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) study, the Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS AKI) study, and Care of Outpatients with AKI (COPE-AKI). He directs the Yale Kidney BioBank, which is currently recruiting participants undergoing a kidney biopsy and banking biosamples to support research efforts of other investigators.
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Clinical Care
Overview
Dennis Moledina, MD, PhD, is a nephrologist (kidney specialist) who directs the Yale Kidney BioBank, which collects samples of kidney tissue, DNA, plasma, and urine to better understand kidney diseases and develop treatments.
Dr. Moledina's work revolves around evaluating biomarkers for acute interstitial nephritis, a lesion that causes a decline in kidney function, and acute kidney injury. He is the recipient of several National Institutes of Health (NIH) research awards and enrolls study participants in NIH-funded consortia, including the Kidney Precision Medicine Program (KPMP) and care of outpatients with acute kidney injury (COPE-AKI).
He obtained clinical training through a clinical fellowship in nephrology and research training through postdoctoral fellowship and an investigative medicine doctorate at Yale University. Notably, his research experience includes leading the enrollment of a group of more than 750 participants concurrent with their kidney biopsy to create the Yale Kidney BioBank. In this group, he has identified diagnostic and prognostic biomarkers of acute interstitial nephritis.
Dr. Moledina is a fellow of the American Society of Nephrology. This designation honors members who have distinguished themselves through excellent work and clinical practice.
Clinical Specialties
Links & Media
News
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- February 26, 2024
Reanalyzing the Impact of COVID-19 on the Kidneys
- November 18, 2023Source: Parade
How Many Times a Day Is It 'Normal' To Pee?