RAndomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial
Volunteers
Health Professionals
What is the purpose of this trial?
This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizumab versus atezolizumab alone in patients who have already received atezolizumab plus chemotherapy for the treatment of small cell lung cancer that has spread outside of the lung or to other parts of the body (extensive stage). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving radiation therapy in addition to atezolizumab may extend the time without extensive small cell lung cancer growing or spreading compared to atezolizumab alone.
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Principal Investigator
Sub-Investigators
- Abhijit Patel, MD, PhD
- Allison Campbell, MD, PhD
- Anca Bulgaru, MD
- Andrea Brennan
- Anne Chiang, MD, PhD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Bruce A. McGibbon, MD
- Catherine Wei, MD
- Christin A. Knowlton, MD, MA
- D. Barry Boyd, MD, MS
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Emily Duffield, APRN
- Emily Kopas, APRN, OCN
- Frederick Wilson, MD, PhD
- Harold Tara Jr, MD
- James Laird, MD
- James E. Hansen, MD, MS
- Jason Haldas, MD
- John Glendening
- Julie Kang, MD, PhD
- Justin Persico, MD
- Kathleen Fenn, MD
- Kenneth B. Roberts, MD
- Kevin Du, MD, PhD, MSCI
- Kimberly L. Johung, MD, PhD
- Larisa Fleysher
- Marianne Davies, NP, DNP, MSN, BSN
- Matthew Austin, MD
- Meena S. Moran, MD
- Melissa Rasar Young, MD, PhD
- Michael Cohenuram, MD
- Nadine Housri, MD
- Neal Fischbach, MD
- Rebecca Vanasse-Passas, MD
- Robert Legare, MD
- Roy S. Herbst, MD, PhD
- Sanjay Aneja, MD
- Sarah Carlson
- Sarah Goldberg, MD, MPH
- Scott Gettinger, MD
- So Yeon Kim, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Susan A. Higgins, MD
- Thomas Hayman, MD, PhD
- Vanna Dest
- Wajih Kidwai, MD, FACP
- Yi An, MD
- Last Updated11/26/2024
- Study HIC#2000033846