2022
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis
An S, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D. Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2208947119. PMID: 36417441, PMCID: PMC9860279, DOI: 10.1073/pnas.2208947119.Peer-Reviewed Original ResearchConceptsPI-3K/Akt pathwayAkt pathwayAkt activationDocking protein Gab1EGF-stimulated activationEpithelial cellsLive-cell imagingPhosphoinositide-3 kinaseCell survival pathwaysExocyst complexExocyst functionSmall molecule inhibitorsVesicle tethersExocytic fusionProtein Gab1EGF stimulationExocystSurvival pathwaysExocytosisInhibitors resultsPathwayImportant pathwayEGFR inhibitionMinute time scaleVesicles
2017
Diverse p53/DNA binding modes expand the repertoire of p53 response elements
Vyas P, Beno I, Xi Z, Stein Y, Golovenko D, Kessler N, Rotter V, Shakked Z, Haran T. Diverse p53/DNA binding modes expand the repertoire of p53 response elements. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 10624-10629. PMID: 28912355, PMCID: PMC5635862, DOI: 10.1073/pnas.1618005114.Peer-Reviewed Original ResearchConceptsP53 response elementNatural response elementsResponse elementTetrameric complexCanonical p53 response elementBulk genomic DNAAdjacent spacer sequencesCanonical binding siteP53 binding siteExpression of genesBinding sitesCellular outcomesTranscription factorsDNA sitesP53 bindsSpacer sequencesP53 actsP53 dimersSpecific complexDimer bindsGenomic DNABase pairsPhysiological relevanceFunctional significanceSecond binds
2004
Predicting indirect readout effects in protein–DNA interactions
Zhang Y, Xi Z, Hegde RS, Shakked Z, Crothers DM. Predicting indirect readout effects in protein–DNA interactions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 8337-8341. PMID: 15148366, PMCID: PMC420395, DOI: 10.1073/pnas.0402319101.Peer-Reviewed Original Research