2021
Extracellular cap domain is an essential component of the TRPV1 gating mechanism
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12: 2154. PMID: 33846324, PMCID: PMC8041747, DOI: 10.1038/s41467-021-22507-3.Peer-Reviewed Original ResearchConceptsCap domainC-terminusIon conductance pathwaysNumerous physiological processesTransient receptor potential channelsTRP channel familyCryo-EMPhysiological processesChannel familyExtracellular entranceHuman diseasesGating mechanismΒ-sheetConductance pathwayCritical determinantMolecular sensorsOpen probabilityPotential channelsIon selectivityEssential componentTRPV1 functionDomainTerminusProteinDeletion
2019
Mammalian TRP ion channels are insensitive to membrane stretch
Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B. Mammalian TRP ion channels are insensitive to membrane stretch. Journal Of Cell Science 2019, 132: jcs238360. PMID: 31722978, PMCID: PMC6918743, DOI: 10.1242/jcs.238360.Peer-Reviewed Original ResearchConceptsTRP channelsTouch-insensitive mutantsMembrane stretchIon channelsTRP ion channel familyIon channel familyTransient receptor potential (TRP) ion channelsTRP ion channelsMammalian subfamiliesMammalian membersPotential ion channelsArtificial bilayer systemInsensitive mutantsCytoplasmic tethersDownstream componentsMechanosensory processesSignaling cascadesChannel familyCellular componentsBlood pressure regulationCell membraneCerebrospinal fluid flowMechanical forcesStretch activationPressure regulation