2021
Extracellular cap domain is an essential component of the TRPV1 gating mechanism
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12: 2154. PMID: 33846324, PMCID: PMC8041747, DOI: 10.1038/s41467-021-22507-3.Peer-Reviewed Original ResearchConceptsCap domainC-terminusIon conductance pathwaysNumerous physiological processesTransient receptor potential channelsTRP channel familyCryo-EMPhysiological processesChannel familyExtracellular entranceHuman diseasesGating mechanismΒ-sheetConductance pathwayCritical determinantMolecular sensorsOpen probabilityPotential channelsIon selectivityEssential componentTRPV1 functionDomainTerminusProteinDeletion
2015
Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons
Nikolaev Y, Dosen P, Laver D, van Helden D, Hamill O. Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons. Brain Research 2015, 1608: 1-13. PMID: 25765154, DOI: 10.1016/j.brainres.2015.02.051.Peer-Reviewed Original ResearchConceptsHippocampal pyramidal neuronsPyramidal neuronsChannel currentsSpike activityAction potentialsRhythmic spike activityCell-attached patch recordingsTraumatic brain injuryCerebellar Purkinje neuronsMouse brain slicesCation channel currentsCentral neuronsBrain injuryLocus coeruleusBrain slicesSynaptic inputsVoltage-gated channelsPurkinje neuronsPatch recordingsInward currentsMammalian brainNeuron typesNeuronsMechanosensitive organCation channels