2018
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
Martinac B, Bavi N, Ridone P, Nikolaev YA, Martinac AD, Nakayama Y, Rohde PR, Bavi O. Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile. Biophysical Reviews 2018, 10: 1377-1384. PMID: 30182202, PMCID: PMC6233343, DOI: 10.1007/s12551-018-0450-3.Peer-Reviewed Original ResearchTransbilayer pressure profileMS channelsIon channel mechanosensitivityLipid bilayersMechanosensitive ion channelsSubmillisecond time scaleMembrane lipid environmentStructure-function relationshipsChannel mechanosensitivityMembrane proteinsDownstream effectorsLipid environmentIntracellular signalsCellular membranesConformational changesBiophysical principlesChannel reconstitutionIon channelsMechanical stimuliTime scalesPressure profileSpecific interactionsMechanical forcesCentral roleReconstitution method
2015
Lipid–protein interactions: Lessons learned from stress
Battle A, Ridone P, Bavi N, Nakayama Y, Nikolaev Y, Martinac B. Lipid–protein interactions: Lessons learned from stress. Biochimica Et Biophysica Acta 2015, 1848: 1744-1756. PMID: 25922225, DOI: 10.1016/j.bbamem.2015.04.012.Peer-Reviewed Original ResearchConceptsLipid-protein interactionsMS channelsLipid bilayersRegulation of cellMechanosensitive membrane channelsMechanosensitive proteinsMembrane proteinsCellular compartmentsTransmembrane portionProkaryotic systemIntracellular signalsPhysical barrierPhysiological processesHypoosmotic shockMembrane channelsMS proteinBiological membranesProteinVariety of rolesCell lysisNormal functionIntracellular spaceEukaryotesCardiac hypertrophyMuscular dystrophy