2023
Molecular insights into the force-from-lipids gating of mechanosensitive channels
Bavi N, Cox C, Nikolaev Y, Martinac B. Molecular insights into the force-from-lipids gating of mechanosensitive channels. Current Opinion In Physiology 2023, 36: 100706. DOI: 10.1016/j.cophys.2023.100706.Peer-Reviewed Original ResearchMS channel gatingChannel gatingLipid bilayersMechanosensitive ion channelsLipid principleMechanosensitive channelsChannel proteinsPhysiological processesMolecular underpinningsMolecular insightsMembrane tensionIon channelsMolecular interactionsMechanical forcesCurrent understandingBilayer thinningNew insightsGatingBilayersBlood pressure regulationProteinRegulationInsightsCellsPressure regulation
2020
Chapter Three Cell membrane mechanics and mechanosensory transduction
Martinac B, Nikolaev Y, Silvani G, Bavi N, Romanov V, Nakayama Y, Martinac A, Rohde P, Bavi O, Cox C. Chapter Three Cell membrane mechanics and mechanosensory transduction. Current Topics In Membranes 2020, 86: 83-141. PMID: 33837699, DOI: 10.1016/bs.ctm.2020.08.002.Peer-Reviewed Original ResearchConceptsCell mechanicsCell membrane mechanicsMechanosensitive ion channelsGene expressionIntracellular signalsMechanosensory transductionMolecular transducersIon channelsMechanical stimuliMembrane mechanicsCurrent knowledgeMechanical forcesMillisecond timescaleStimuli actCellsTransductionRapid progressNew toolMechanobiologyBiological cellsBetter understandingPathwayExpression
2018
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
Martinac B, Bavi N, Ridone P, Nikolaev YA, Martinac AD, Nakayama Y, Rohde PR, Bavi O. Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile. Biophysical Reviews 2018, 10: 1377-1384. PMID: 30182202, PMCID: PMC6233343, DOI: 10.1007/s12551-018-0450-3.Peer-Reviewed Original ResearchTransbilayer pressure profileMS channelsIon channel mechanosensitivityLipid bilayersMechanosensitive ion channelsSubmillisecond time scaleMembrane lipid environmentStructure-function relationshipsChannel mechanosensitivityMembrane proteinsDownstream effectorsLipid environmentIntracellular signalsCellular membranesConformational changesBiophysical principlesChannel reconstitutionIon channelsMechanical stimuliTime scalesPressure profileSpecific interactionsMechanical forcesCentral roleReconstitution method
2017
Principles of Mechanosensing at the Membrane Interface
Bavi N, Nikolaev Y, Bavi O, Ridone P, Martinac A, Nakayama Y, Cox C, Martinac B. Principles of Mechanosensing at the Membrane Interface. Springer Series In Biophysics 2017, 19: 85-119. DOI: 10.1007/978-981-10-6244-5_4.Peer-Reviewed Original ResearchChannel mechanosensitivityTransbilayer pressure profileIon channel mechanosensitivitySpecific cellular responsesMechanosensitive ion channelsMolecular mechanosensorsCellular mechanotransductionIntracellular signalsPhysiological processesCellular responsesMechanosensory transducersLiving cellsExtracellular matrixIon channelsChannel conformationLipid bilayersMembrane interfaceMechanotransductionMechanosensitivityMechanical stimuliCellsCytoskeletonMechanosensorsLipidsConformationAdding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling
Friedrich O, Schneidereit D, Nikolaev Y, Nikolova-Krstevski V, Schürmann S, Wirth-Hücking A, Merten A, Fatkin D, Martinac B. Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling. Progress In Biophysics And Molecular Biology 2017, 130: 170-191. PMID: 28647645, DOI: 10.1016/j.pbiomolbio.2017.06.011.Peer-Reviewed Original ResearchConceptsFocal adhesion complexesCell-substrate junctionLive-cell imagingMechanosensitive ion channelsDirect mechanistic studiesAdhesion complexesCellular mechanotransductionMembrane junctionsIntracellular signalingMechanotransduction researchCellular stretchCellular modelIon channelsCellular levelCell membraneMechanotransductionIndividual cardiomyocytesBiomedical engineeringMechanical wall stressMembraneMechanistic studiesCellsStretch deviceCardiomyocytesElastomeric membrane