2007
Proteomic Analysis of the Resistance to Aplidin in Human Cancer Cells
González-Santiago L, Alfonso P, Suárez Y, Núñez A, García-Fernández LF, Alvarez E, Muñoz A, Casal JI. Proteomic Analysis of the Resistance to Aplidin in Human Cancer Cells. Journal Of Proteome Research 2007, 6: 1286-1294. PMID: 17338558, DOI: 10.1021/pr060430+.Peer-Reviewed Original ResearchConceptsProtein disulfide isomeraseRole of PDINumber of proteinsRab geranylgeranyltransferaseInduction of apoptosisHuman cancer cellsDisulfide isomeraseProteomic approachMembrane proteinsProteomic analysisMALDI-TOF mass spectrometryApoptosis pathwayDatabase interrogationHeLa cellsCyclophilin AProteinCancer cellsAplidinApoptosisCystathionine gamma lyaseCellsMass spectrometryGeranylgeranyltransferaseEzrinIsomerase
2006
Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content
Suárez Y, González-Santiago L, Zarich N, Dávalos A, Aranda JF, Alonso MA, Lasunción MA, Rojas JM, Muñoz A. Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content. Molecular Pharmacology 2006, 70: 1654-1663. PMID: 16928956, DOI: 10.1124/mol.106.025569.Peer-Reviewed Original ResearchConceptsJun N-terminal kinaseMembrane cholesterol contentRac1-JNK pathwayHeLa cellsWild-type HeLa cellsMembrane-bound Rac1Plasma membrane cholesterolRac1 small GTPaseN-terminal kinaseMKP-1 phosphataseJNK pathway activationCellular bindingMDA-MB-231 breast cancer cellsInduction of apoptosisSmall GTPaseMarine cyclic depsipeptidePlasma membraneJNK activationRac1 activationMembrane cholesterolCell deathSubcellular fractioningBreast cancer cellsSustained activationRac1