2024
Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study
Aierken A, Zhuang J, Yang S, Yalikun D, Xu C, Zhang C, Tian X, Jiang H. Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202486qykah2. DOI: 10.1681/asn.202486qykah2.Peer-Reviewed Original ResearchAtypical Hemolytic Uremic Syndrome with Peripheral Gangrene
Aierken A, Muhetaer G, Yang S, Zhuang J, Jiang H, Tian X. Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20244hj831a8. DOI: 10.1681/asn.20244hj831a8.Peer-Reviewed Original ResearchPodocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases
Shen Z, Zhang C, Zhuang J, Qu Y, Tian X, Jiang H. Podocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024y382k1hb. DOI: 10.1681/asn.2024y382k1hb.Peer-Reviewed Original ResearchWIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seqFallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies.
Chen X, Chen Z, Du Y, Tian X, Fu R. Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies. AME Case Rep 2024, 8: 66. PMID: 39091550, DOI: 10.21037/acr-23-201.Peer-Reviewed Case Reports and Technical NotesClinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study
Ha X, Zhao Z, Zhao T, Muhetaer G, Wang X, Bao A, Duan Y, Zhuang J, Song X, Zhou Y, Zhang Q, Wu J, Fan M, Zhang L, Tian X, Jiang H. Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study. Integrative Medicine In Nephrology And Andrology 2024, 11: e23-00018. DOI: 10.1097/imna-d-23-00018.Peer-Reviewed Original ResearchSARS-CoV-2 Omicron infectionMaintenance hemodialysisClinical characteristicsMHD patientsSARS-CoV-2 Omicron variantSARS-CoV-2Disease severityFollow-upSerum C-reactive protein levelsOmicron infectionRisk factorsC-reactive protein levelsFollow-up assessmentIndependent risk factorSpectrum of disease severityChinese adult patientsTailored treatment strategiesNegative nucleic acidAdult MHD patientsMaintenance hemodialysis patientsHigh-risk populationArterial oxygen partial pressureOmicron variantProcalcitonin levelsPrognostic factorsZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024, 106: 419-432. PMID: 38797325, PMCID: PMC11343665, DOI: 10.1016/j.kint.2024.05.007.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cellsReduced endothelial nitric oxideRegulator of vascular barrier functionEndothelial nitric oxide signalingENOS activityEndosome-associated proteinsBarrier functionKidney organ culturesEndothelial nitric oxideAkt-dependent mannerNitric oxide donorGTPase Rab5Nitric oxide signalingZFYVE21Live cell imagingKidney insufficiencyReporter miceTrafficking mechanismsAccelerated aging phenotypeKnockout miceInterstitial edemaKidney functionVesicular populationOxide donorMediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis
Zhou X, Jiang H, Zhou Y, Wang X, Ren H, Tian X, Zhang Q. Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis. World Journal Of Psychiatry 2024, 14: 409-420. PMID: 38617988, PMCID: PMC11008395, DOI: 10.5498/wjp.v14.i3.409.Peer-Reviewed Original ResearchQuality of lifeSocial supportSocial Support Rating ScaleMental well-being of patientsLevels of social supportOveral quality of lifeImpact of social supportSelf-Rating Anxiety ScaleQuality of Life ScaleSelf-Rating Depression ScaleWell-being of patientsSelf-ratingsMental well-beingQuality of life of patientsDepression ScaleEffects of dysphoriaPsychological issuesAnxiety ScaleRating ScaleDysphoriaMaintenance hemodialysisMediation roleRandom sampling approachSupportDespondencyDPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways. Toxicology Letters 2024, 395: 1-10. PMID: 38458339, DOI: 10.1016/j.toxlet.2024.03.001.Peer-Reviewed Original ResearchHuman mesangial cellsAkt signaling pathwayExtracellular matrixSignaling pathwayDipeptidyl peptidase IVMesangial cellsExpression of ECM-related proteinsPhosphorylation of AktECM-related proteinsAbnormal extracellular matrixECM depositionExcessive deposition of extracellular matrixPhosphorylation of Smad2DPP8/9 inhibitionDeposition of extracellular matrixGlomerular mesangial cellsDPP9Collagen IVDPP8AktMultiple diseasesDPP8/9SiRNAPathogenesis of glomerular diseaseCellsA comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy
Ma X, Wang R, Wei L, Liu P, Jing L, Wang J, Dong W, Tian X, Fu R. A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy. Practical Laboratory Medicine 2024, 39: e00385. PMID: 38495349, PMCID: PMC10940994, DOI: 10.1016/j.plabm.2024.e00385.Peer-Reviewed Original ResearchAnti-PLA2R antibodiesEnzyme-linked immunosorbent assayNegative predictive valuePositive predictive valueAnti-PLA2RMembranous nephropathyChemiluminescence immunoassayLevels of anti-PLA2R antibodiesPhospholipase A2 receptor antibodyPredictive valuePrimary membranous nephropathyPhospholipase A2 receptorImmunosorbent assayResults Serum levelsStatistical analysis of sensitivityROC curve analysisNon-membranous nephropathyStatistically significant differencePMN groupReceptor antibodiesSerum levelsA2 receptorsSpearman correlation analysisDiagnostic valueNephropathyClinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series
Qu Y, Zhuang J, Duan Y, Baibutihan A, Maimaiti Z, Zhang C, Niu J, Teng W, Ailimu M, Wei X, Qi B, Li J, Du S, Wang D, Cao K, Wang J, Lu C, Tian X, Jiang H. Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series. Integrative Medicine In Nephrology And Andrology 2024, 11: e00019. DOI: 10.1097/imna-d-23-00019.Peer-Reviewed Original ResearchKidney transplant recipientsKT recipientsClinical characteristicsKidney transplantationTransplant recipientsElevated serum D-dimerIncidence of severe infectionsOmicron infectionSevere/critical illnessOutcomes of severe acute respiratory syndrome coronavirus 2Calcineurin inhibitor drugsSerum D-dimerSerum albumin levelSARS-CoV-2Acute kidney injuryFollow-up periodC-reactive proteinSARS-CoV-2 Omicron infectionSARS-CoV-2 Omicron variantReverse transcription polymerase chain reactionImmunocompromised statusFerritin levelsTranscription polymerase chain reactionSevere/critical groupAntiviral therapyEditorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy
Chen H, Tian X, Yu X. Editorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy. Frontiers In Endocrinology 2024, 15: 1359011. PMID: 38332890, PMCID: PMC10852059, DOI: 10.3389/fendo.2024.1359011.Commentaries, Editorials and LettersCharacteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis
Wang Y, Wang H, Ma X, Zhu Z, Tian X, Fu R, Jia L. Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis. BMC Nephrology 2024, 25: 35. PMID: 38273279, PMCID: PMC10811929, DOI: 10.1186/s12882-024-03465-6.Peer-Reviewed Original ResearchConceptsIgAN patientsFibrinogen degradation productsIgA nephropathyIgAVN patientsLevels of plasma D-dimerLevels of serum creatininePartial remission rateSevere coagulation abnormalitiesPlasma D-dimerPoor renal functionChronic kidney injuryRemission ratePathological resultsSerum creatinineAbdominal symptomsRenal functionCoagulation abnormalitiesDeposition of fibrinogenKidney biopsyD-dimerKidney injuryCoagulation functionIgAVNIgAN groupMethodsA totalUnderstanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy
Jiang H, Shen Z, Zhuang J, Lu C, Qu Y, Xu C, Yang S, Tian X. Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy. Frontiers In Immunology 2024, 14: 1335936. PMID: 38288116, PMCID: PMC10822972, DOI: 10.3389/fimmu.2023.1335936.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseGlomerular filtration barrierProteinuric glomerular diseasesKidney diseaseGlomerular diseaseImmune responseFiltration barrierTherapeutic targetCell-like characteristicsFocal segmental glomerulosclerosisProteinuric kidney diseaseTargets of immune responsesDamage to podocytesLupus nephritisPotential therapeutic targetGlomerular basement membraneImmune injuryGlomerular injuryMembranous nephropathyFenestrated endothelial cellsKidney functionSegmental glomerulosclerosisAdaptive immunityEpithelial cellsPathogenic mechanismsSuccessful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report
Yalikun D, Zhuang J, Lei W, Wang C, Aierken A, Qu Y, Wang J, Tian X, Jiang H. Successful outcome in a case of idiopathic multicentric Castleman disease with atypical lymphadenopathy and kidney injury: Diagnostic challenges and treatment approach—Case report. SAGE Open Medical Case Reports 2024, 12: 2050313x241240097. PMID: 38559411, PMCID: PMC10981217, DOI: 10.1177/2050313x241240097.Peer-Reviewed Case Reports and Technical NotesIdiopathic multicentric Castleman diseaseCastleman's diseaseMulticentric Castleman's diseaseSignificant lymphadenopathySystemic inflammationKidney injuryCases of idiopathic multicentric Castleman's diseaseMonths of follow-upLymph node biopsyUrinary tract infectionAnti-infective treatmentPatient's clinical symptomsAcute kidney injuryNo significant lymphadenopathyLoss of appetiteNode biopsySymptomatic recurrencePersistent feverTract infectionsMultiorgan involvementRenal functionDiagnostic challengeInflammatory markersCase reportFavorable outcome
2023
Editorial: Autophagy and hypoxia-inducible factor in diabetes.
Guo J, Tian X, Liu H, Liu WJ. Editorial: Autophagy and hypoxia-inducible factor in diabetes. Front Endocrinol (Lausanne) 2023, 14: 1349432. PMID: 38164495, DOI: 10.3389/fendo.2023.1349432.Commentaries, Editorials and LettersProfilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases
Tian X, Pedigo C, Li K, Ma X, Bunda P, Pell J, Lek A, Gu J, Zhang Y, Rangel P, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S, Priyadarshini A, Zhao H, Lek M, Menon M, Fu R, Ishibe S. Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases. Journal Of Clinical Investigation 2023, 133: e171237. PMID: 37847555, PMCID: PMC10721156, DOI: 10.1172/jci171237.Peer-Reviewed Original ResearchConceptsProteinuric kidney diseaseKidney diseasePodocyte lossHuman glomerular diseasesMitotic catastrophePodocyte cell cycleSevere proteinuriaCell cycle reentryKidney failureGlomerular diseaseCell cycleKidney tissueG1/S checkpointUnsuccessful repairCyclin D1Glomerular integrityIrregular nucleiTissue-specific lossMouse podocytesPodocytesAltered expressionDiseaseCyclin B1Ribosome affinity purificationMultinucleated cellsUncovering the Role of Cyclin G-Associated Kinase (GAK) in Regulating the Podocyte Cytoskeleton
Bunda P, Tian X, Inoue K, Ishibe S. Uncovering the Role of Cyclin G-Associated Kinase (GAK) in Regulating the Podocyte Cytoskeleton. Journal Of The American Society Of Nephrology 2023, 34: 302-303. DOI: 10.1681/asn.20233411s1302d.Peer-Reviewed Original ResearchIgG4-Related Disease with IgG1-Dominant Membranous Nephropathy: A Rare Case Report
Duan Y, Qu Y, Zhuang J, Abudula R, Zhang C, Tian X, Jiang H. IgG4-Related Disease with IgG1-Dominant Membranous Nephropathy: A Rare Case Report. Integrative Medicine In Nephrology And Andrology 2023, 10: e00007. DOI: 10.1097/imna-d-23-00007.Peer-Reviewed Case Reports and Technical NotesMembranous nephropathyClinical remissionIgG4-RDNephrotic syndromeIgG4-related tubulointerstitial nephritisRare pathological featureComplete clinical remissionPrimary membranous nephropathyRare case reportGlucocorticoid therapyPLA2R stainingKidney involvementMaintenance therapyRituximab treatmentRTX treatmentImmunoglobulin G4Tubulointerstitial nephritisKidney biopsySubepithelial depositionPathological featuresCase reportFibroinflammatory disorderAntigen stainingNephropathyReceptor antigenCase report: Genotype-phenotype characteristics of nine novel PKD1 mutations in eight Chinese patients with autosomal dominant polycystic kidney disease
Zhuang J, Aierken A, Yalikun D, Zhang J, Wang X, Ren Y, Tian X, Jiang H. Case report: Genotype-phenotype characteristics of nine novel PKD1 mutations in eight Chinese patients with autosomal dominant polycystic kidney disease. Frontiers In Medicine 2023, 10: 1268307. PMID: 37901409, PMCID: PMC10600478, DOI: 10.3389/fmed.2023.1268307.Peer-Reviewed Case Reports and Technical NotesAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseKidney diseasePolycystic kidney diseaseWhole-exome sequencingNovel mutation sitesDisease progressionNovel PKD1 mutationChronic kidney diseaseRapid disease progressionGene mutationsGenotype-phenotype characteristicsPeripheral blood DNAPersonalized therapeutic strategiesAge of onsetMilder disease phenotypeCommon genetic disorderAutosomal dominant inheritancePolycystic liverADPKD patientsChinese patientsClinical dataTherapeutic strategiesClinical phenotypeEarly onset