About
Titles
Associate Research Scientist
Departments & Organizations
- Chen Lab
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xinxin Nie's published research.
Publications
2022
Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Glez-Vaz J, Azpilikueta A, Olivera I, Cirella A, Teijeira A, Ochoa MC, Alvarez M, Eguren-Santamaria I, Luri-Rey C, Rodriguez-Ruiz ME, Nie X, Chen L, Guedan S, Sanmamed M, Gracia J, Melero I. Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies. Journal For ImmunoTherapy Of Cancer 2022, 10: e003532. PMID: 35236742, PMCID: PMC8896037, DOI: 10.1136/jitc-2021-003532.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMouse CD8 T cellsCD8 T cellsChimeric antigen receptorT cellsCD137 costimulationHuman CD137Surface expressionAnti-CD137 monoclonal antibodiesCAR-transduced T cellsCostimulatory molecule CD137Sequential plasma samplesCAR T cellsBasis of efficacyMouse tumor modelsProtein expression levelsCD137 agonistsSoluble CD137First patientSyngeneic tumorsAgonist agentsPharmacodynamic biomarkersClinical trialsPlasma concentrationsDynamic biomarkersSCD137
2017
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb
Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2017, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRepulsive guidance molecule bT cell responsesB7-DCPD-1T cellsB7-DC/PDCoinhibitory receptor PD-1T helper 1 responseTh2-mediated asthmaSmall airway inflammationReceptor PD-1T cell inhibitionExperimental mouse modelNaive mouse T cellsMouse T cellsAirway inflammationTh1 polarizationTh1 responseDendritic cellsLung pathologyMouse modelCostimulatory functionCostimulatory receptorsCD4Costimulation
Get In Touch
Contacts
Email