Featured Publications
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 2016, 354: 765-768. PMID: 27846608, PMCID: PMC5640175, DOI: 10.1126/science.aaf7532.Peer-Reviewed Original ResearchConceptsCell deathDNA sensor AIM2New therapeutic targetsCaspase-1-dependent deathIntestinal epithelial cellsBone marrow cellsGastrointestinal syndromeTissue injuryInflammasome activationGastrointestinal tractRadiation-induced cell deathRadiation-induced DNA damageTherapeutic targetAcute exposureBone marrowChemotherapeutic agentsMarrow cellsRadiation exposureAIM2Massive cell deathEpithelial cellsHematopoietic failureDeathMolecular mechanismsDNA damage
2001
Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
Ouyang X, Takahashi K, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells. Journal Of Pharmacological Sciences 2001, 87: 289-296. PMID: 11829148, DOI: 10.1254/jjp.87.289.Peer-Reviewed Original ResearchConceptsCultured neonatal rat cardiac cellsAng IIRat cardiac cellsNeonatal rat cardiac cellsCardiac cellsHypertrophic responseSalvia miltiorrhizaImmediate early response gene expressionAng II actionAng II stimulationChronotropic responsivenessAngiotensin IIMorphological injuryDose-dependent cytotoxicityII stimulationProtective effectEarly response gene expressionDifferent pharmacological activitiesEthyl acetate insoluble fractionResponse gene expressionTanshinone IIAHypertrophic growthPharmacological activitiesCardiomyocytesEffective constituents