2023
An Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease
Jing XZ, Yuan XZ, Luo X, Zhang SY, Wang XP. An Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease. Current Neuropharmacology 2023, 21: 1806-1826. PMID: 35193486, PMCID: PMC10514518, DOI: 10.2174/1570159x20666220222150811.Peer-Reviewed Original ResearchMeSH KeywordsAntiparkinson AgentsDopamineDyskinesiasHumansLevodopaParkinson DiseaseSerotoninZonisamideConceptsNon-motor symptomsDopamine replacement therapyPD patientsMotor fluctuationsParkinson's diseaseNondopaminergic treatmentsReplacement therapyCertain non-motor symptomsTraditional dopamine replacement therapyLower urinary tract symptomsUrinary tract symptomsOngoing clinical trialsPotential adverse eventsManagement of motorPositive clinical implicationsManagement of hallucinationsDopaminergic strategiesMotor complicationsNondopaminergic drugsPD psychosisOrthostatic hypotensionTract symptomsAdverse eventsClinical benefitClinical efficacy
2016
Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjects