2022
Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesCognitionHumansPrefrontal CortexRetrospective StudiesSchizophreniaConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScores
2020
Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Hong L, Tan Y. Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study. Neuroscience Letters 2020, 742: 135548. PMID: 33279570, DOI: 10.1016/j.neulet.2020.135548.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaRight postcentral gyrusInferior frontal gyrusPostcentral gyrusSchizophrenic patientsWhole brain resting-state functional connectivity (rsFC) analysisMotor circuitsLeft primary motor cortexRight supplementary motor areaFunctional connectivityPathogenesis of TDResting-state fMRI studyResting-state functional connectivity analysisFrontal gyrusAIMS total scoreLeft triangular partPrimary motor cortexAbnormal functional connectivityRight superior parietal lobuleSupplementary motor areaNegative Syndrome ScaleNon-TD groupSuperior parietal lobuleBilateral parietal cortex
2016
Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjects
2013
Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder
Kong L, Chen K, Womer F, Jiang W, Luo X, Driesen N, Liu J, Blumberg H, Tang Y, Xu K, Wang F. Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder. Journal Of Psychiatric Research 2013, 47: 733-739. PMID: 23453566, PMCID: PMC3626116, DOI: 10.1016/j.jpsychires.2013.02.003.Peer-Reviewed Original ResearchConceptsMajor depressive disorderHealthy controlsGray matter morphologyDepressive disorderPrefrontal cortexSex differencesHigh-resolution structural magnetic resonanceSignificant GM reductionsFemale healthy controlsLeft ventral prefrontal cortexStructural magnetic resonanceNeural systemsVentral prefrontal cortexClinical presentationLimbic regionsMedication-naïve participantsClinical aspectsRight hippocampusStriatal regionsBilateral caudateRight amygdalaHC groupGM reductionSex-related patternsMDD females