2016
Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
Zhu X, Yuan J, Zhu T, Li Y, Cheng X. Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3. The FEBS Journal 2016, 283: 3739-3754. PMID: 27573079, DOI: 10.1111/febs.13839.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAlpha-FetoproteinsAnimalsBiomarkers, TumorCarcinoma, HepatocellularCell Line, TumorDisease ProgressionEpigenesis, GeneticGlypicansHep G2 CellsHeterograftsHistonesHumansLiver NeoplasmsMiceMice, NudePrognosisPromoter Regions, GeneticRNA, AntisenseRNA, Long NoncodingTranscriptional ActivationUp-RegulationConceptsHCC cell proliferationBarcelona Clinic Liver Cancer stageCell proliferationTranscript 1Inhibited HCC cell proliferationLiver Cancer stageHepatocellular carcinoma screeningPotential therapeutic targetXenograft tumor growthHepatocellular carcinoma progressionP300/CBP-associated factorWorse prognosisCarcinoma screeningMicrovascular invasionTumor sizeHCC patientsCancer stageTherapeutic targetHCC progressionTumor growthCarcinoma progressionPotential biomarkersPathophysiological processesHCC tissuesSignificant upregulation
2015
ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand
Peng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, Cheng X, Xu T. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports 2015, 13: 387-398. PMID: 26440887, DOI: 10.1016/j.celrep.2015.09.002.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 3Itch sensationPrimary sensory neuronsIon channel 3ASIC3 geneSL-NH2Concomitant inflammationScratching behaviorPathological changesCoincident stimulationTissue acidosisASIC3 channelsSensory neuronsAcidosisNonproton ligandPruritogensSensationIle-GlyChannel 3Arg-LeuInflammationItchMiceNeuronsDesensitizationCytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit
Lu W, Qiu L, Yan Z, Lin Z, Cao M, Hu C, Wang Z, Wang J, Yu Y, Cheng X, Cao P, Li R. Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit. Oncotarget 2015, 6: 34537-34548. PMID: 26417929, PMCID: PMC4741471, DOI: 10.18632/oncotarget.5307.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntigen PresentationBlotting, WesternCancer VaccinesCholera ToxinDisease Models, AnimalEpitopes, B-LymphocyteFemaleFluorescent Antibody TechniqueLymphocyte ActivationMiceMice, Inbred C57BLMinisatellite RepeatsMucin-1Polymerase Chain ReactionT-Lymphocytes, CytotoxicVaccines, SubunitConceptsCytotoxic T lymphocytesMUC1-specific cytotoxic T lymphocytesElicit cytotoxic T lymphocyteCytotoxic T cell responsesT cell responsesCancer vaccine designCholera toxin B subunitToxin B subunitB-cell epitopesMUC1 vaccineTumor burdenCancer vaccinesTh1 cellsT cellsT lymphocytesMouse modelCell epitopesTumor growthCell responsesTumor tissueVaccine designTumor MUC1Antigen designVaccineMUC1 peptide
2006
Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells
Cheng X, Jaggar J. Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells. AJP Heart And Circulatory Physiology 2006, 290: h2309-h2319. PMID: 16428350, PMCID: PMC1698957, DOI: 10.1152/ajpheart.01226.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBariumCadmiumCalcium SignalingCaveolin 1ElectrophysiologyEnzyme InhibitorsFluorescent DyesFura-2IndolesMiceMice, KnockoutMicroscopy, ConfocalMicroscopy, ElectronMuscle, Smooth, VascularMyocytes, Smooth MuscleNitroargininePatch-Clamp TechniquesRyanodine Receptor Calcium Release ChannelConceptsCerebral artery smooth muscle cellsSmooth muscle cellsArtery smooth muscle cellsMuscle cellsMurine arterial smooth muscle cellsGenetic ablationNitric oxide synthase activityVoltage-dependent calcium channelsArterial smooth muscle cellsOxide synthase activitySmooth muscle contractilityChannel blockersMuscle contractilityCalcium channelsCav-1-deficient cellsSpark regulationL-typeElevated intracellularSpark frequencyPotassium channelsSarcoplasmic reticulumCurrent activationCav-1Control cellsRelease channel