2009
The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractility
Bannister J, Adebiyi A, Cheng X, Zhao G, Jaggar J. The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractility. The FASEB Journal 2009, 23: 775.13-775.13. DOI: 10.1096/fasebj.23.1_supplement.775.13.Peer-Reviewed Original ResearchVoltage-dependent Ca 2Cerebral arteryMyogenic toneArterial myocytesRat cerebral arteriesCerebral artery myocytesMyogenic constrictionAcute applicationMajor Ca 2Membrane-permeant peptidePhysiological functionsSubunit expressionArteryProtein expressionE1CGreater reductionMyocytesControl peptideShRNAEntry pathwayCa 2N-terminal variantsSplice variants
2007
A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*
Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister J, Dopico A, Jaggar J. A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*. Journal Of Biological Chemistry 2007, 282: 29211-29221. PMID: 17699517, PMCID: PMC2276565, DOI: 10.1074/jbc.m610623200.Peer-Reviewed Original ResearchConceptsExon 1cN-terminusExon 1bAuxiliary subunitsRich N-terminusCysteine-rich N-terminusNovel alternative splicingResistance-size cerebral arteriesPlasma membrane insertionExon 1Arterial myocytesMultiple vascular functionsIsoform-dependent differencesWhole-cell current densityN-terminal variantsAlternative splicingMembrane insertionChannel regulationExon 1AMolecular identityHuman diseasesSubunitsTerminusEntry pathwaySmooth muscle cellsMyocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus
Cheng X, Liu J, Blaskova E, Asuncion‐Chin M, Bondarenko A, Dopico A, Jaggar J. Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus. The FASEB Journal 2007, 21: a1240-a1240. DOI: 10.1096/fasebj.21.6.a1240-c.Peer-Reviewed Original ResearchResistance-size arteriesIBa densityVoltage-dependent L-type Ca2Resistance-sized cerebral arteriesL-type Ca2Tissue-specific Ca2Cerebral arteryArterial myocytesSmall arteriesVascular pressuresBlood flowArteryCav1.2 geneCardiac myocytesMyocytesCav1.2 channelsCaV1.2 currentsCav1.2 subunitCysteine-rich N-terminusEntry pathwayHalf activationSpecific Ca2Principal Ca2ß-subunitHalf inactivation