2020
Regulation and Function of RNA Pseudouridylation in Human Cells
Borchardt EK, Martinez NM, Gilbert WV. Regulation and Function of RNA Pseudouridylation in Human Cells. Annual Review Of Genetics 2020, 54: 1-28. PMID: 32870730, PMCID: PMC8007080, DOI: 10.1146/annurev-genet-112618-043830.Peer-Reviewed Original ResearchConceptsRNA pseudouridylationHuman cellsRNA-binding proteinDistinct RNA sequencesMRNA pseudouridylationPseudouridine synthasesMolecular functionsRNA metabolismPseudouridylationGene expressionRNA conformationRNA targetsProtein productionRNA sequencesMessenger RNADiverse classRNATherapeutic mRNAWidespread effectsDestabilizing interactionsCellsRecent advancesSplicingSynthasesPotential effects
2016
Messenger RNA modifications: Form, distribution, and function
Gilbert WV, Bell TA, Schaening C. Messenger RNA modifications: Form, distribution, and function. Science 2016, 352: 1408-1412. PMID: 27313037, PMCID: PMC5094196, DOI: 10.1126/science.aad8711.Peer-Reviewed Original ResearchConceptsStable noncoding RNAsMRNA target siteOrganismal phenotypesDevelopmental regulatorsNoncoding RNAsMRNA modificationMolecular consequencesMessenger RNAMolecular effectsRNATarget siteRecent technical advancesDistinct modificationsSparse modificationEpitranscriptomeSplicingMethyladenosineRegulatorSpeciesTechnical advancesModificationPhenotypeRegulationFunctionCells
2014
Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
Carlile TM, Rojas-Duran MF, Zinshteyn B, Shin H, Bartoli KM, Gilbert WV. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature 2014, 515: 143-146. PMID: 25192136, PMCID: PMC4224642, DOI: 10.1038/nature13802.Peer-Reviewed Original Research