1997
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
Zhong W, Jiang M, Weinmaster G, Jan L, Jan Y. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 1997, 124: 1887-1897. PMID: 9169836, DOI: 10.1242/dev.124.10.1887.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCerebral CortexCloning, MolecularCytoplasmDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGenesIntracellular Signaling Peptides and ProteinsJuvenile HormonesMembrane ProteinsMiceModels, NeurologicalMolecular Sequence DataMorphogenesisMutationNerve Tissue ProteinsNervous SystemNeuronsOrgan SpecificityReceptor, Notch1Receptors, Cell SurfaceRecombinant Fusion ProteinsRNA, MessengerSequence Homology, Amino AcidStem CellsTranscription FactorsConceptsDaughter cellsNeural precursorsMammalian cortical neurogenesisAsymmetric cell divisionSignificant sequence similarityMouse cortical neurogenesisCortical neurogenesisEmbryonic nervous systemFunction mutant embryosCell-cell interactionsCell-intrinsic mechanismsMammalian NumbMouse NumbNumb lossProgenitor cell proliferationDrosophila neurogenesisMammalian genesMutant embryosCell-extrinsic mechanismsSequence similarityCell divisionDifferential segregationNumblikePostmitotic neuronsNumb
1990
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Sladek F, Zhong W, Lai E, Darnell J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development 1990, 4: 2353-2365. PMID: 2279702, DOI: 10.1101/gad.4.12b.2353.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCell NucleusCloning, MolecularDNA-Binding ProteinsGene ExpressionHepatocyte Nuclear Factor 4LiverMacromolecular SubstancesMaleMolecular Sequence DataMultigene FamilyOligonucleotide ProbesPhosphoproteinsRatsRats, Inbred StrainsReceptors, SteroidRecombinant ProteinsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticConceptsSteroid hormone receptor superfamilyHNF-4 proteinHNF-4Hormone receptor superfamilyReceptor superfamilyTranscription factor HNF-4Regulation of transcriptionAmino acid sequencePyruvate kinase geneLigand-dependent transcription factorSequence-specific fashionDNA binding activityPolymerase chain reactionHNF-4 mRNANorthern blot analysisUnusual amino acidsLF-A1CDNA clonesActivate transcriptionBinding to sitesZinc fingerCotransfection assaysDNA bindingSynthetic oligonucleotidesTranscription factors