2008
Neurogenesis and asymmetric cell division
Zhong W, Chia W. Neurogenesis and asymmetric cell division. Current Opinion In Neurobiology 2008, 18: 4-11. PMID: 18513950, DOI: 10.1016/j.conb.2008.05.002.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsAsymmetric divisionMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cellsCellular diversityGlial progenyCell divisionCell biologyNeuronal lineageNeural progenitorsCentral nervous systemDivisionNeurogenesisDrosophilaVertebratesCellsLineagesNervous systemBiologyProgenyProgenitorsDiversityNeuroblastsSimilarity
2007
The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis
Zhou Y, Atkins JB, Rompani SB, Bancescu DL, Petersen PH, Tang H, Zou K, Stewart SB, Zhong W. The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis. Cell 2007, 129: 163-178. PMID: 17418793, DOI: 10.1016/j.cell.2007.02.037.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCell DivisionCell LineageCytosolDrosophilaEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGolgi ApparatusMembrane ProteinsMiceMitosisNerve Tissue ProteinsNeuronsPhenotypeProtein Structure, TertiaryReceptors, GABA-ASignal TransductionStem CellsConceptsCell fate specificationNumb proteinDaughter cellsGolgi fragmentationCell cycleMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cell cycleProgenitor cellsCell cycle progressionNeural progenitor cellsMammalian GolgiCell fateCell divisionNeuronal fateACBD3Golgi apparatusSubcellular distributionNeuronal differentiationPhenotypic similarityNumbMitosisNeuron productionProteinCells
2006
The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis
Petersen PH, Tang H, Zou K, Zhong W. The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis. Developmental Neuroscience 2006, 28: 156-168. PMID: 16508312, DOI: 10.1159/000090761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationCell DivisionCell LineageDrosophila melanogasterEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGenes, HomeoboxMammalsMembrane ProteinsMesodermMiceMice, Mutant StrainsMutationNerve Tissue ProteinsProtein IsoformsReceptors, NotchSomitesStem CellsConceptsAsymmetric cell divisionAntagonistic rolesCell divisionCell fate specificationStem cell maintenanceDefective Notch signalingEmbryonic nervous systemStem/progenitor cellsMammalian embryogenesisNeural stem/progenitor cellsFate specificationCell fateNumb proteinCell maintenanceNumb isoformsMammalian neurogenesisMolecular basisNotch signalingDifferent fatesNumbDifferential regulationStem cellsProgenitor cellsEmbryogenesisPremature depletion
2005
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Developmental Biology 2005, 279: 155-168. PMID: 15708565, DOI: 10.1016/j.ydbio.2004.12.010.Peer-Reviewed Original Research
2004
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
Petersen PH, Zou K, Krauss S, Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nature Neuroscience 2004, 7: 803-811. PMID: 15273690, DOI: 10.1038/nn1289.Peer-Reviewed Original ResearchConceptsMouse NumbProgenitor cellsEarly neurogenesisAsymmetric cell divisionProgenitor cell maintenanceLoss of NumbNeural progenitor cellsProgenitor cell depletionDrosophila melanogasterCell fateCell divisionNeuronal fateNumblNumbCortical neurogenesisStem cellsGeneral mechanismDorsal forebrainNeurogenesisCellsNervous systemFateSpecific malformationsDifferent neuronsMelanogaster
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Shen Q, Zhong W, Jan YN, Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002, 129: 4843-53. PMID: 12361975, DOI: 10.1242/dev.129.20.4843.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionMouse cortical developmentCell fateStem cellsProgenitor cellsDiverse cell fatesNeural cell fateMouse cortical neurogenesisNext cell divisionEmbryonic mouse cortexDrosophila neurogenesisProgenitor marker nestinAsymmetric segregationLineage treesNumb proteinCortical stem cellsMouse homologueNotch activityWild typeNumbNeuronal differentiationNeuronal cellsCortical neurogenesisCortical developmentProgenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
2000
Mouse numb is an essential gene involved in cortical neurogenesis
Zhong W, Jiang M, Schonemann M, Meneses J, Pedersen R, Jan L, Jan Y. Mouse numb is an essential gene involved in cortical neurogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6844-6849. PMID: 10841580, PMCID: PMC18761, DOI: 10.1073/pnas.97.12.6844.Peer-Reviewed Original ResearchConceptsEssential genesDaughter cellsProgenitor cellsCranial neural tube closureFunction mutant allelesApical daughter cellMembrane-associated proteinsProgenitor cell fateCortical neurogenesisNeural tube closureEmbryonic day 11.5Neural progenitor cellsCortical progenitor cellsNumb functionsCell fateApical cell membraneNumb geneSevere defectsTube closureMutant allelesNeural developmentDay 11.5Cell membraneGenesMammalian neocortex