Featured Publications
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultBayes TheoremCritical IllnessDeliriumHumansNetwork Meta-AnalysisRandomized Controlled Trials as TopicRespiration, ArtificialConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchMeSH KeywordsExerciseHumansLife StyleNeoplasmsPrognosisRandomized Controlled Trials as TopicWeight LossConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials RegistryCitation impact was highly variable for reporting guidelines of health research: a citation analysis
Caulley L, Cheng W, Catalá-López F, Whelan J, Khoury M, Ferraro J, Husereau D, Altman DG, Moher D. Citation impact was highly variable for reporting guidelines of health research: a citation analysis. Journal Of Clinical Epidemiology 2020, 127: 96-104. PMID: 32712175, DOI: 10.1016/j.jclinepi.2020.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAuthorshipBibliometricsConfidence IntervalsData AnalysisGuidelines as TopicJournal Impact FactorPeriodicals as TopicRandomized Controlled Trials as TopicResearch ReportSex FactorsTime Factors
2022
Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis
Bailey A, Maganti H, Cheng W, Shorr R, Buchan C, Allan D. Humoral and Cellular Response of Transplant Recipients to a Third Dose of mRNA SARS-CoV-2 Vaccine: A Systematic Review and Meta-analysis. Transplantation 2022, 107: 204-215. PMID: 36398334, PMCID: PMC9746229, DOI: 10.1097/tp.0000000000004386.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, ViralChildCOVID-19COVID-19 VaccinesHumansRandomized Controlled Trials as TopicRNA, MessengerSARS-CoV-2Transplant RecipientsConceptsMRNA SARS-CoV-2 vaccineSARS-CoV-2 vaccinesTransplant recipientsThird doseSystematic reviewMeta-analysisNational Institutes of Health Quality Assessment ToolCochrane risk of bias toolAssociated with reduced oddsRisk of bias toolDose of mRNA SARS-CoV-2 vaccineMeta-Analysis reporting guidelinesQuality assessment toolHumoral responseSARS-CoV-2 mRNA vaccinesPreferred Reporting ItemsDerSimonian-Laird random-effects modelRandomized controlled trialsAdult transplant recipientsRandom-effects modelLack of controlled studiesClinically relevant thresholdsResponse to vaccinationCochrane riskReporting Items
2021
VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis
Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis. CHEST Journal 2021, 161: 418-428. PMID: 34419428, DOI: 10.1016/j.chest.2021.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticoagulantsCritical IllnessHeparinHeparin, Low-Molecular-WeightHumansIntermittent Pneumatic Compression DevicesPulmonary EmbolismRandomized Controlled Trials as TopicVenous ThromboembolismConceptsIncidence of DVTRandomized clinical trialsMechanical compressive deviceRisk of DVTIll adultsCombination therapyRCTs of patientsSystematic reviewAdults A Systematic ReviewCombination pharmacologic therapyCompressive devicePrimary pharmacologic agentsRisk of VTELow-certainty evidencePrevention of VTEA Systematic ReviewNetwork Meta-AnalysisFull-text reviewThromboprophylaxis agentsVenous thromboprophylaxisVTE prophylaxisRecommendations AssessmentPharmacologic therapyPulmonary embolismIll patientsWhat Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Meulenkamp B, Woolnough T, Cheng W, Shorr R, Stacey D, Richards M, Gupta A, Fergusson D, Graham ID. What Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Clinical Orthopaedics And Related Research® 2021, 479: 2119-2131. PMID: 34180874, PMCID: PMC8445578, DOI: 10.1097/corr.0000000000001861.Peer-Reviewed Original ResearchMeSH KeywordsAchilles TendonEvidence-Based MedicineHumansRandomized Controlled Trials as TopicRuptureTendon InjuriesConceptsAcute Achilles tendon ruptureAchilles tendon ruptureTendon ruptureRisk of reruptureOpen surgeryLower riskFunctional rehabilitationSystematic reviewRandom-effects Bayesian networkPatient-reported outcome scoresPatient-reported outcome measuresPrimary immobilizationSmall sample sizeGrades of RecommendationOpen surgical repairRisk of complicationsMultiple treatment optionsNetwork Meta-AnalysisRandomized Controlled TrialsMeta-analysis extension statementSpecific patient populationsStudy treatment armsConsiderable clinical heterogeneityPreferred Reporting ItemsRisk of performance
2019
Pharmacological interventions for the treatment of delirium in critically ill adults
Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. 2019, 9: cd011749. PMID: 31479532, PMCID: PMC6719921, DOI: 10.1002/14651858.cd011749.pub2.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsCritical IllnessDeliriumHumansNetwork Meta-AnalysisRandomized Controlled Trials as TopicConceptsTreatment of deliriumIntensive care unitComa-free daysDuration of deliriumNon-pharmacological interventionsLong-term outcomesIll adultsPharmacological interventionsMechanical ventilationAgonist dexmedetomidineDrug classesICU stayIll patientsReview authorsPatient outcomesOvid MEDLINELonger intensive care unitLong-term cognitive outcomesActive drug treatmentAvailable pharmacological interventionsMultiple pharmacological interventionsLonger ICU stayIll adult patientsResolution of symptomsHigh dependency unit