1991
Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat.
Quagliarello V, Ma A, Stukenbrok H, Palade G. Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat. Journal Of Experimental Medicine 1991, 174: 657-672. PMID: 1875166, PMCID: PMC2118932, DOI: 10.1084/jem.174.3.657.Peer-Reviewed Original ResearchConceptsBlood-brain barrierBBB injuryExperimental meningitisCerebral microvasculatureOpen intercellular junctionsSpecific therapeutic interventionsBacterial meningitisBrain barrierIntracisternal inoculationMeningitisBrain cortexInjury mechanismMicrovascular segmentsTherapeutic interventionsIntercellular junctionsInducible increaseAu-BSAInjuryAbluminal sidePrecise mechanismSimilar uptakeAlbumin transportColloidal carbonTracer perfusionVenular leaks
1986
Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase