2021
A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis.
Holtrop M, Heltshe S, Shabanova V, Keller A, Schumacher L, Fernandez L, Jain R. A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis. Annals Of The American Thoracic Society 2021, 18: 1158-1166. PMID: 33544657, DOI: 10.1513/annalsats.202008-1064oc.Peer-Reviewed Original ResearchConceptsLung functionSex hormonesCystic fibrosisInflammatory markersProinflammatory cytokinesHormone concentrationsEthinyl estradiol/norethindroneRegular menstrual cyclesSubset of subjectsHormone contraceptionPeak estrogenAirway inflammationPulmonary exacerbationsInflammatory biomarkersRespiratory symptomsHormonal contraceptivesHormonal contraceptionProspective studyContraceptive pillsMenstrual cycleSymptom questionnaireWorse outcomesStudy visitRespiratory pathogensClinical impact
2019
Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, Brenton JN, Cabre P, Carra Dallière C, de Seze J, Durand Dubief F, Inglese M, Langille M, Mathey G, Neuteboom RF, Pelletier J, Pohl D, Reich DS, Ignacio Rojas J, Shabanova V, Shapiro ED, Stone RT, Tenembaum S, Tintoré M, Uygunoglu U, Vargas W, Venkateswaren S, Vermersch P, Kantarci O, Okuda DT, Pelletier D, . Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Multiple Sclerosis Journal - Experimental Translational And Clinical 2019, 5: 2055217319836664. PMID: 30915227, PMCID: PMC6429663, DOI: 10.1177/2055217319836664.Peer-Reviewed Original ResearchOligoclonal bandsMultiple sclerosisCerebrospinal fluidDiagnostic criteriaCentral nervous system demyelinationMagnetic resonance imaging criteriaFirst clinical eventCerebrospinal fluid analysisNervous system demyelinationOptimal diagnostic criteriaDiagnostic indexMagnetic resonanceSpecificity 72.7Historical cohortProspective studyClinical eventsMRI criteriaSensitivity 66.7Imaging criteriaDiagnostic certaintySpecificity 83.3SyndromeFluid analysisSensitivity 76.5Demyelination
2013
Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV‐Infected Children in Accra
Langs-Barlow A, Renner L, Katz K, Northrup V, Paintsil E. Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV‐Infected Children in Accra. AIDS Research And Treatment 2013, 2013: 249171. PMID: 23533730, PMCID: PMC3606755, DOI: 10.1155/2013/249171.Peer-Reviewed Original ResearchMitochondrial Disease CriteriaMitochondrial toxicityNaïve childrenCharts of HIVHAART naïve childrenResource-poor settingsHAART exposureHAART initiationHIV diagnosisHIV infectionTherapy toxicityHIV managementClinical symptomsProspective studyClinical criteriaDisease criteriaHAARTYounger ageHIVMitochondrial damageSignificant differencesChildrenToxicityScoresExposure