2023
Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance
Natov P, Ivey-Miranda J, Cox Z, Moreno-Villagomez J, Maulion C, Bellumkonda L, Shlipak M, Estrella M, Borlaug B, Rao V, Testani J. Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance. Circulation Heart Failure 2023, 16: e009776. PMID: 36700431, PMCID: PMC10150783, DOI: 10.1161/circheartfailure.122.009776.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureDecompensated heart failureStable renal functionGlomerular filtration rateRenal functionRenal tubular injuryHeart failureTubular injuryKIM-1Filtration rateRenal tubular injury markersTubular injury markersRenal function groupCumulative urine outputCardiorenal dysfunctionDiuretic dosesInjury markersWorse survivalWorsened survivalUrine outputDecongestive therapyPrognostic importanceAdverse outcomesLower admissionPatients
2020
Renal Negative Pressure Treatment as a Novel Therapy for Cardio-Renal Syndrome
Maulion C, Asher J, Moskow J, Ivey-Miranda J, Fleming J, Gleason O, Meegan G, Rao V, Testani J. Renal Negative Pressure Treatment as a Novel Therapy for Cardio-Renal Syndrome. Journal Of Cardiac Failure 2020, 26: s6-s7. DOI: 10.1016/j.cardfail.2020.09.027.Peer-Reviewed Original ResearchUrine outputNegative pressure treatmentCreatinine clearanceLoop diureticsTubular pressureAcute decompensated heart failure hospitalizationHF inductionElevated filling pressuresHigh-dose furosemidePrimary therapeutic objectiveCardio-renal syndromeHeart failure hospitalizationHeart failure modelUrinary collecting systemStable cardiac outputDose furosemideCardiac tamponadeFailure hospitalizationSodium excretionHemodynamic profileRenal functionKidney functionR kidneysSwan-GanzCardiac output
2019
Safety and Efficacy of an Auto-Titrating Diuretic Protocol: A Pilot
Griffin M, Flemming J, Pattoli M, Stewart B, Gomez N, Barnett J, Thomas A, Wycallis E, Struyk G, Shamlian P, Mahoney D, Ivey-Miranda J, Ivey-Miranda J, Rao V, Testani J. Safety and Efficacy of an Auto-Titrating Diuretic Protocol: A Pilot. Journal Of Cardiac Failure 2019, 25: s52. DOI: 10.1016/j.cardfail.2019.07.147.Peer-Reviewed Original ResearchDiuretic resistanceFurosemide equivalentsRenal functionBlood pressureHeart failureWeight lossHeart failure physiciansNon-randomized pilotTraditional diuretic therapyMajority of patientsSystolic blood pressureRapid dose escalationMaximum daily doseSpot urine samplesDiuretic doseDiuretic protocolDiuretic therapyDiuretic dosesHF patientsSodium excretionStarting doseElectrolyte abnormalitiesHospital daysDaily doseDose escalationSarcopenia Strongly Affects Serum Levels of Cystatin C in Patients with Heart Failure
Ivey-Miranda J, Stewart B, Gomez N, Barnett J, Thomas A, Wycallis E, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Mahoney D, Griffin M, Rao V, Testani J. Sarcopenia Strongly Affects Serum Levels of Cystatin C in Patients with Heart Failure. Journal Of Cardiac Failure 2019, 25: s20-s21. DOI: 10.1016/j.cardfail.2019.07.059.Peer-Reviewed Original ResearchGlomerular filtration rateSerum cystatin CSerum cystatin C levelsHeart failureCystatin C levelsCystatin CSerum creatinineMuscle massCreatinine clearanceSerum levelsCystatin C serum levelsDecompensated heart failureC levelsC serum levelsUrine creatinine excretionLow muscle massCreatinine excretion rateRenal functionLess muscle massLowest tertileUse of creatinineCreatinine excretionFiltration rateUnivariate analysisUrine collection
2018
The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function
Mahoney D, Ahmad T, Rao V, Brisco-Bacik M, Wilson F, Siew E, Felker G, Anstrom K, Bart B, Tang W, O'Connor C, Velazquez E, Testani J. The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function. Journal Of Cardiac Failure 2018, 24: s26. DOI: 10.1016/j.cardfail.2018.07.074.Peer-Reviewed Original ResearchRenal tubular injury biomarkersTubular injury biomarkersRenal tubular injuryHeart failure patientsInjury biomarkersTubular injuryFailure patientsRenal functionAcute decompensated heart failure patientsDecompensated heart failure patientsVolume removalCARRESS-HF trialRenal function recoveryTubular injury markersWorsening Renal FunctionHalf of patientsADHF patientsEffective decongestionRenal effectsInjury markersPharmacologic therapyTransient findingFunction recoveryHigh incidencePatients
2017
007 Acute Tubular Injury is Not a Major Mechanism for Worsening Renal Function in Patients Treated for Acute Heart Failure
Hodson D, Jackson K, Ahmad T, Rao V, Mahoney D, Tarleton C, Chunara Z, Thomas D, Chen M, Jacoby D, Riello R, Testani J. 007 Acute Tubular Injury is Not a Major Mechanism for Worsening Renal Function in Patients Treated for Acute Heart Failure. Journal Of Cardiac Failure 2017, 23: s6. DOI: 10.1016/j.cardfail.2017.07.010.Peer-Reviewed Original Research