2018
The Germline-Specific Factor OEF-1 Facilitates Coordinated Progression Through Germ Cell Development in Caenorhabditis elegans
McManus CE, Reinke V. The Germline-Specific Factor OEF-1 Facilitates Coordinated Progression Through Germ Cell Development in Caenorhabditis elegans. Genetics 2018, 208: 549-563. PMID: 29167199, PMCID: PMC5788521, DOI: 10.1534/genetics.117.1123.Peer-Reviewed Original ResearchConceptsGerm cell developmentGerm cellsCell developmentGermline-expressed genesNovel nuclear proteinCell cycle checkpointsGermline expressionGenomic integrityUnique fateOocyte differentiationFaithful transmissionCycle checkpointsNuclear proteinsMature gametesX chromosomeDevelopmental eventsLarval stagesMaturation eventsGenetic materialCaenorhabditisFactor 1Developmental progressionSubtle defectsCellsExpression
2006
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network
Derry W, Bierings R, van Iersel M, Satkunendran T, Reinke V, Rothman J. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Cell Death & Differentiation 2006, 14: 662-670. PMID: 17186023, DOI: 10.1038/sj.cdd.4402075.Peer-Reviewed Original ResearchConceptsCEP-1Genotoxic stressP53 family membersComplex transcriptional regulatory networksDevelopmental rateTranscriptional regulatory networksCell proliferationP53-binding siteGerm cell proliferationTumor suppressor p53Absence of stressGermline apoptosisCaenorhabditis elegansTranscriptional networksC. elegansMammalian counterpartsCheckpoint responseGene networksRegulatory networksTranscriptional targetsP53 gene networkEmbryonic viabilityHuman p63Negative regulatorP53 family