2020
Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers
Ogden A, Bhattarai S, Sahoo B, Mongan N, Alsaleem M, Green A, Aleskandarany M, Ellis I, Pattni S, Li X, Moreno C, Krishnamurti U, Janssen E, Jonsdottir K, Rakha E, Rida P, Aneja R. Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports 2020, 10: 3009. PMID: 32080212, PMCID: PMC7033213, DOI: 10.1038/s41598-020-59514-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic AgentsBiomarkers, TumorCohort StudiesErbB ReceptorsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMammary Glands, HumanMiddle AgedNeoplasm StagingNF-kappa BPoly (ADP-Ribose) Polymerase-1PrognosisReceptor, ErbB-3Survival AnalysisThioredoxinsTriple Negative Breast NeoplasmsTumor Suppressor Protein p53
2017
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer
Ogden A, Garlapati C, Li X, Turaga R, Oprea-Ilies G, Wright N, Bhattarai S, Mittal K, Wetherilt C, Krishnamurti U, Reid M, Jones M, Gupta M, Osan R, Pattni S, Riaz A, Klimov S, Rao A, Cantuaria G, Rida P, Aneja R. Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer. Scientific Reports 2017, 7: 42289. PMID: 28218233, PMCID: PMC5316996, DOI: 10.1038/srep42289.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalProgression-free survivalTNBC cellsOverall survivalPoor prognosisBreast cancerTriple-negative breast cancer patientsTriple-negative breast cancerMultivariable Cox modelMetastasis-free survivalWorse overall survivalBreast cancer patientsMulti-institutional studyAA TNBC patientsAfrican AmericansAfrican American womenTNBC patientsIndependent biomarkerPrognostic valueCancer patientsWorse outcomesCox modelTissue microarrayKIFC1 knockdownTNBC