2007
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Krishnamurti U, Sasatomi E, Swalsky P, Finkelstein S, Ohori N. Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations? Archives Of Pathology & Laboratory Medicine 2007, 131: 74-80. PMID: 17227126, DOI: 10.5858/2007-131-74-aolohi.Peer-Reviewed Original ResearchConceptsK-ras mutationsBile duct brushingsLoss of heterozygosityMalignant outcomeFractional allelic lossDuct brushingsCytology casesAllelic lossMolecular alterationsBile duct brushing cytologyPilot studyConventional cytologic evaluationSurgical pathology specimenCorresponding surgical specimensDuct brushing cytologySurgical pathology specimensDetection of malignancySubtle molecular alterationsSurgical outcomesSurgical specimenPathology specimenCytologic findingsSurgical specimensBrushing cytologyCytologic evaluation
2006
The “Big Dog” Effect: Variability Assessing the Causes of Error in Diagnoses of Patients With Lung Cancer
Raab S, Meier F, Zarbo R, Jensen D, Geisinger K, Booth C, Krishnamurti U, Stone C, Janosky J, Grzybicki D. The “Big Dog” Effect: Variability Assessing the Causes of Error in Diagnoses of Patients With Lung Cancer. Journal Of Clinical Oncology 2006, 24: 2808-2814. PMID: 16782918, DOI: 10.1200/jco.2005.04.3661.Peer-Reviewed Original ResearchConceptsKappa statisticsQuality improvement interventionsDiagnosis of patientsFalse-negative diagnosesInstitutional pathologistsLung massSurgical specimenLung cancerPathology specimenPulmonary specimensReview diagnosisSlide reviewPatientsImprovement interventionsOriginal diagnosisInter-pathologist agreementPsychosocial hypothesesClinical samplingDiagnosisInterobserver agreementCancer diagnosisDiagnostic samplesInitial assessmentSame institutionDiagnostic errors