Transgenic RNAi Depletion of Claudin-16 and the Renal Handling of Magnesium*
Hou J, Shan Q, Wang T, Gomes A, Yan Q, Paul D, Bleich M, Goodenough D. Transgenic RNAi Depletion of Claudin-16 and the Renal Handling of Magnesium*. Journal Of Biological Chemistry 2007, 282: 17114-17122. PMID: 17442678, DOI: 10.1074/jbc.m700632200.Peer-Reviewed Original ResearchConceptsClaudin-16Tight junction proteinsTight junction proteins claudin-16Junction proteinsRenal handlingTight junctionsRenal handling of magnesiumRenal wasting of magnesiumParacellular ion reabsorptionHandling of magnesiumKnock-downFamilial hypomagnesemiaRenal functionElectrolyte disordersCation channelsTarget of drug developmentAscending limbMouse modelFHHNCParacellular cation channelsControl of ion homeostasisRenal controlIn vivo analysisIon reabsorptionNephrocalcinosisBlocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice
Yan Q, Du Z, Duan Y, Weinbaum S, Weinstein A, Wang T. Blocking angiotensin II type 2 receptor (AT2) induces diuresis and natriuresis in AT1A receptor‐deficient mice. The FASEB Journal 2007, 21: a1246-a1246. DOI: 10.1096/fasebj.21.6.a1246-c.Peer-Reviewed Original ResearchGlomerular filtration rateAT1A receptor-deficient miceReceptor-deficient miceUrine volumeAT2 receptorsNa+ excretionAngiotensin II type 2 receptorAdministration of PD123319Handling of Na+Type 2 receptorRenal handling of Na+Renin-angiotensin systemArterial blood pressureRegulation of Na+KO miceIntravenous bolusPD123319Renal clearanceFiltration rateRenal handlingInduce diuresisReceptor functionFluid homeostasisBlood pressureAT1A